Latest Articles
Commentary | Host-Microbe BiologymSphere of Influence: an Inupiat Journey in ScienceDr. Kathryn Milligan-Myhre works in the field of host-microbe interactions. In this mSphere of Influence article, she reflects on the people and scientific ideas that influenced her journey from a small town in Alaska to a faculty position at the University of Alaska Anchorage.
Research Article | Host-Microbe BiologyAntibody-Dependent Dengue Virus Entry Modulates Cell Intrinsic Responses for Enhanced InfectionDengue virus is the most prevalent mosquito-borne viral infection globally, resulting in variable manifestations ranging from asymptomatic viremia to life-threatening shock and multiorgan failure. Previous studies have indicated that the risk of severe dengue in humans can be increased by a specific range of preexisting anti-dengue virus antibody titers, a phenomenon termed antibody-dependent enhancement. There is hence a need to...
Research Article | Host-Microbe BiologyRecovirus NS1-2 Has Viroporin Activity That Induces Aberrant Cellular Calcium Signaling To Facilitate Virus ReplicationTulane virus is one of many enteric caliciviruses that cause acute gastroenteritis and diarrheal disease. Globally, enteric caliciviruses affect both humans and animals and amass >65 billion dollars per year in treatment and health care-associated costs, thus imposing an enormous economic burden. Recent progress has resulted in several cultivation systems (B cells, enteroids, and zebrafish larvae) to study human noroviruses, but...
Research Article | Applied and Environmental ScienceSituations Leading to Reduced Effectiveness of Current Hand Hygiene against Infectious Mucus from Influenza Virus-Infected PatientsAntiseptic hand rubbing (AHR) and antiseptic hand washing (AHW) are important to prevent the spread of influenza A virus (IAV). This study elucidated the situations/mechanisms underlying the reduced efficacy of AHR against infectious mucus derived from IAV-infected individuals and indicated the weaknesses of the current hand hygiene regimens. Due to the low rate of diffusion/convection because of the physical properties of mucus as a...
Observation | Clinical Science and EpidemiologyFirst Report of blaVIM-4- and mcr-9-Coharboring Enterobacter Species Isolated from a Pediatric PatientWe describe the complete genome assembly and sequence of a clinical Enterobacter isolate harboring both blaVIM-4 and mcr-9 recovered from a pediatric patient in the United States with a history of travel to Egypt. Moreover, to the best of our knowledge, this is the first report of an Enterobacter isolate harboring both blaVIM-4 and mcr-9 from the United States....
Editor's Pick Research Article | Molecular Biology and PhysiologyGlobal Transcriptomic Analysis of the Candida albicans Response to Treatment with a Novel Inhibitor of FilamentationThese results from whole-genome transcriptional profiling provide further insights into the biological activity and mode of action of a small-molecule inhibitor of C. albicans filamentation. This information will assist in the development of novel antivirulence strategies against C. albicans...
![Identification of 4-Amino-Thieno[2,3-<em>d</em>]Pyrimidines as QcrB Inhibitors in <span class="named-content genus-species" id="named-content-1">Mycobacterium tuberculosis</span>](https://msphere.asm.org/sites/default/files/styles/thumbnail/public/externals/7b56615af4441ab7b2840e5d31309242.jpg?itok=kywyIsdP)
Research Article | Therapeutics and PreventionIdentification of 4-Amino-Thieno[2,3-d]Pyrimidines as QcrB Inhibitors in Mycobacterium tuberculosisThe global tuberculosis (TB) epidemic has been exacerbated by the rise in drug-resistant TB cases worldwide. To tackle this crisis, it is necessary to identify new vulnerable drug targets in Mycobacterium tuberculosis, the causative agent of TB, and develop compounds that can inhibit the bacterium through novel mechanisms of action. The QcrB subunit of the electron...
Research Article | Clinical Science and EpidemiologyCharacterization of a Multidrug-Resistant Porcine Klebsiella pneumoniae Sequence Type 11 Strain Coharboring blaKPC-2 and fosA3 on Two Novel Hybrid PlasmidsThe global dissemination of carbapenem resistance genes is of great concern. Animals are usually considered a reservoir of resistance genes and an important source of human infection. Although carbapenemase-producing Enterobacteriaceae strains of animal origin have been reported increasingly, blaKPC-2-positive strains from food-producing animals are still rare. In this study, we first describe the isolation...
Research Article | Ecological and Evolutionary ScienceGenomic Variation among Strains of Crithidia bombi and C. expoekiA group of trypanosomatid flagellates includes several well-studied medically and economically important parasites of vertebrates and plants. Nevertheless, the vast majority of trypanosomatids infect only insects (mostly flies and true bugs) and, because of that, has attracted little research attention in the past. Of several hundred trypanosomatid species, only four can infect bees (honeybees and bumblebees). Because of such scarcity,...
Research Article | Clinical Science and EpidemiologySerological Array-in-Well Multiplex Assay Reveals a High Rate of Respiratory Virus Infections and Reinfections in Young ChildrenThe multiplex immunoassay was successfully used to simultaneously detect antibodies against seven different viruses. The developed serological microarray is a new promising tool for diagnostic, epidemiological, and seroprevalence analyses of virus infections.