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Editor's Pick Research Article | Host-Microbe BiologyImpact of Amoxicillin-Clavulanate followed by Autologous Fecal Microbiota Transplantation on Fecal Microbiome Structure and Metabolic PotentialThe spread of multidrug resistance among pathogenic organisms threatens the efficacy of antimicrobial treatment options. The human gut serves as a reservoir for many drug-resistant organisms and their resistance genes, and perturbation of the gut microbiome by antimicrobial exposure can open metabolic niches to resistant pathogens. Once established in the gut, antimicrobial-resistant bacteria can persist even after antimicrobial...
Research Article | Molecular Biology and PhysiologyGenetic Analysis of NDT80 Family Transcription Factors in Candida albicans Using New CRISPR-Cas9 ApproachesTranscription factors play key roles in regulating virulence of the human fungal pathogen C. albicans. In addition to regulating the expression of virulence factors, they also control the ability of C. albicans to switch to filamentous hyphal growth, which facilitates biofilm formation on medical...
Research Article | Host-Microbe BiologyThe Protective Role of Bacteroides fragilis in a Murine Model of Colitis-Associated Colorectal CancerThe incidence of colorectal cancer (CRC) is rapidly growing worldwide, and there is therefore a greater emphasis on studies of the treatment or prevention of CRC pathogenesis. Recent studies suggested that consideration of the microbiota is unavoidable to understand inflammation and tumorigenesis in the gastrointestinal tract. We demonstrate, using a mouse model of colitis-associated CRC, that human commensal...
Research Article | Host-Microbe BiologyNucleolar Relocalization of RBM14 by Influenza A Virus NS1 ProteinInfluenza A virus (IAV) and respiratory syncytial virus (RSV) present major global disease burdens. There are high economic costs associated with morbidity as well as significant mortality rates, especially in developing countries, in children, and in the elderly. There are currently limited therapeutic options for these viruses, which underscores the need for novel research into virus biology that may lead to the discovery of new...
Research Article | Host-Microbe BiologyEchinocandin-Induced Microevolution of Candida parapsilosis Influences Virulence and Abiotic Stress ToleranceCandida parapsilosis is an opportunistic fungal pathogen with the ability to cause infections in immunocompromised patients. Echinocandins are the currently recommended first line of treatment for all Candida species. Resistance of Candida albicans to this drug type is well characterized....
Observation | Molecular Biology and PhysiologySinorhizobium meliloti, a Slow-Growing Bacterium, Exhibits Growth Rate Dependence of Cell Size under Nutrient LimitationThe dependence of cell size on growth rate is a fundamental principle in the field of bacterial cell size regulation. Previous studies of cell size regulation mainly focus on fast-growing bacterial species such as Escherichia coli and Bacillus...
Research Article | Molecular Biology and PhysiologySurface Exposure and Packing of Lipoproteins into Outer Membrane Vesicles Are Coupled Processes in BacteroidesSpecies from the Bacteroides genus are predominant members of the human gut microbiota. OMVs in Bacteroides have been shown to be important for the homeostasis of complex host-commensal relationships, mainly involving immune tolerance and protection from disease. OMVs carry many enzymatic activities involved in the cleavage of complex polysaccharides and have been proposed as public goods that can provide growth to...
Research Article | Host-Microbe BiologyTemporal Variability of Escherichia coli Diversity in the Gastrointestinal Tracts of Tanzanian Children with and without Exposure to AntibioticsThis study increases the number of resident Escherichia coli genome sequences, and explores E. coli diversity through longitudinal sampling. We investigate the genomes of E. coli isolated from human gastrointestinal tracts as part...
Research Article | Host-Microbe BiologyComplement Susceptibility in Relation to Genome Sequence of Recent Klebsiella pneumoniae Isolates from Thai HospitalsMultidrug-resistant Klebsiella pneumoniae is responsible for an increasing proportion of nosocomial infections, and emerging hypervirulent K. pneumoniae clones now cause severe community-acquired infections in otherwise healthy individuals. These bacteria are adept at circumventing immune defenses,...
Research Article | Host-Microbe BiologyThe Buoyancy of Cryptococcus neoformans Is Affected by Capsule SizeThe buoyancy of a microbial cell is an important physical characteristic that may affect its transportability in fluids and interactions with tissues during infection. The polysaccharide capsule surrounding C. neoformans is required for infection and dissemination in the host. Our results indicate that the capsule has a significant effect on reducing cryptococcal cell...