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  • Home
  • Articles
    • Latest Articles
    • COVID-19 Research and News from ASM Journals
    • mSphere of Influence: Commentaries from Early Career Microbiologists
    • Archive
  • Topics
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Latest Articles

  • Serum Antibody Responses against Carbapenem-Resistant <span class="named-content genus-species" id="named-content-1">Klebsiella pneumoniae</span> in Infected Patients
    Research Article
    Serum Antibody Responses against Carbapenem-Resistant Klebsiella pneumoniae in Infected Patients

    Carbapenem-resistant Klebsiella pneumoniae is a rapidly emerging public health threat that can cause fatal infections in up to 50% of affected patients. Due to its resistance to nearly all antimicrobials, development of alternate therapies like antibodies and vaccines is urgently needed.

    Kasturi Banerjee, Michael P. Motley, Elizabeth Diago-Navarro, Bettina C. Fries
    3 Mar 2021
  • Protein Interactomes of <span class="named-content genus-species" id="named-content-1">Streptococcus mutans</span> YidC1 and YidC2 Membrane Protein Insertases Suggest SRP Pathway-Independent- and -Dependent Functions, Respectively
    Research Article | Molecular Biology and Physiology
    Protein Interactomes of Streptococcus mutans YidC1 and YidC2 Membrane Protein Insertases Suggest SRP Pathway-Independent- and -Dependent Functions, Respectively

    Streptococcus mutans is a prevalent oral pathogen and major causative agent of tooth decay. Many proteins that enable this bacterium to thrive in its environmental niche and cause disease are embedded in its cytoplasmic membrane.

    Patricia Lara Vasquez, Surabhi Mishra, Senthil K. Kuppuswamy, Paula J. Crowley, L. Jeannine Brady
    3 Mar 2021
  • Whole-Genome Enrichment and Sequencing of <span class="named-content genus-species" id="named-content-1">Chlamydia trachomatis</span> Directly from Patient Clinical Vaginal and Rectal Swabs
    Research Article
    Whole-Genome Enrichment and Sequencing of Chlamydia trachomatis Directly from Patient Clinical Vaginal and Rectal Swabs

    Chlamydia trachomatis is an obligate intracellular bacterium that is not easily cultured, which limits our understanding of urogenital and rectal C. trachomatis transmission and impact on morbidity. To provide a publicly available workflow for whole-genome target enrichment and sequencing of...

    Katherine E. Bowden, Sandeep J. Joseph, John C. Cartee, Noa Ziklo, Damien Danavall, Brian H. Raphael, Timothy D. Read, Deborah Dean
    3 Mar 2021
  • A Spontaneous <em>rapZ</em> Mutant Impairs Infectivity of Lytic Bacteriophage vB_EcoM_JS09 against Enterotoxigenic <span class="named-content genus-species" id="named-content-1">Escherichia coli</span>
    Research Article
    A Spontaneous rapZ Mutant Impairs Infectivity of Lytic Bacteriophage vB_EcoM_JS09 against Enterotoxigenic Escherichia coli

    The development of phage-resistant bacteria is a challenging problem for phage therapy. However, our knowledge of phage resistance mechanisms is still limited.

    Yan Zhou, Hongduo Bao, Hui Zhang, Maoda Pang, Shujiao Zhu, Ran Wang
    3 Mar 2021
  • Comparative Genomics Reveals Prophylactic and Catabolic Capabilities of <em>Actinobacteria</em> within the Fungus-Farming Termite Symbiosis
    Research Article | Ecological and Evolutionary Science
    Comparative Genomics Reveals Prophylactic and Catabolic Capabilities of Actinobacteria within the Fungus-Farming Termite Symbiosis

    Actinobacteria have repeatedly been isolated in fungus-farming termites, and our genome analyses provide insights into the potential roles they may serve in defense and for plant biomass breakdown. These insights, combined with their relatively higher abundances in fungus combs than in termite gut, suggest that they are more likely to play roles in fungus combs than in termite guts.

    Robert Murphy, René Benndorf, Z. Wilhelm de Beer, John Vollmers, Anne-Kristin Kaster, Christine Beemelmanns, Michael Poulsen
    3 Mar 2021
  • High-Throughput Screen for Inhibitors of the Type IV Pilus Assembly ATPase PilB
    Research Article
    High-Throughput Screen for Inhibitors of the Type IV Pilus Assembly ATPase PilB

    Many bacterial pathogens use their type IV pili (T4P) to facilitate and maintain infection of a human host. Small chemical compounds that inhibit the production or assembly of T4P have promise in the treatment and prevention of infections, especially in the era of increasing threats from antibiotic-resistant bacteria.

    Keane J. Dye, Nancy J. Vogelaar, Pablo Sobrado, Zhaomin Yang
    3 Mar 2021
  • A Point Mutation in the Transcriptional Repressor PerR Results in a Constitutive Oxidative Stress Response in <span class="named-content genus-species" id="named-content-1">Clostridioides difficile</span> 630Δ<em>erm</em>
    Observation
    A Point Mutation in the Transcriptional Repressor PerR Results in a Constitutive Oxidative Stress Response in Clostridioides difficile 630Δerm

    The intestinal pathogen Clostridioides difficile is one of the major challenges in medical facilities nowadays. In order to better combat the bacterium, detailed knowledge of its physiology is mandatory. C. difficile strain 630Δerm was generated in a laboratory from the patient-isolated...

    Daniel Troitzsch, Hao Zhang, Silvia Dittmann, Dorothee Düsterhöft, Timon Alexander Möller, Annika-Marisa Michel, Lothar Jänsch, Katharina Riedel, José Manuel Borrero-de Acuña, Dieter Jahn, Susanne Sievers
    3 Mar 2021
  • Evaluating the Antimicrobial Properties of Commercial Hand Sanitizers
    Editor's Pick Research Article
    Evaluating the Antimicrobial Properties of Commercial Hand Sanitizers

    In response to the coronavirus disease 2019 (COVID-19) pandemic, hand hygiene has taken on a prominent role in efforts to mitigate SARS-CoV-2 transmission and infection, which has led to a radical increase in the number and types of hand sanitizers manufactured to meet public demand. To our knowledge, no studies have evaluated or compared the antimicrobial performance of hand sanitizers that are being produced under COVID-19 emergency...

    M. Chojnacki, C. Dobrotka, R. Osborn, W. Johnson, M. Young, B. Meyer, E. Laskey, R. A. F. Wozniak, S. Dewhurst, P. M. Dunman
    3 Mar 2021
  • Chromatin-Associated Protein Complexes Link DNA Base J and Transcription Termination in <em>Leishmania</em>
    Research Article | Molecular Biology and Physiology
    Chromatin-Associated Protein Complexes Link DNA Base J and Transcription Termination in Leishmania

    Leishmania parasites cause a variety of serious human diseases, with no effective vaccine and emerging resistance to current drug therapy. We have previously shown that a novel DNA base called J is critical for transcription termination at the ends of the polycistronic gene clusters that are a hallmark of Leishmania and related trypanosomatids.

    Bryan C. Jensen, Isabelle Q. Phan, Jacquelyn R. McDonald, Aakash Sur, Mark A. Gillespie, Jeffrey A. Ranish, Marilyn Parsons, Peter J. Myler
    24 Feb 2021
  • Primer, Pipelines, Parameters: Issues in 16S rRNA Gene Sequencing
    Research Article
    Primer, Pipelines, Parameters: Issues in 16S rRNA Gene Sequencing

    In 16S rRNA gene sequencing, certain bacterial genera were found to be underrepresented or even missing in taxonomic profiles when using unsuitable primer combinations, outdated reference databases, or inadequate pipeline settings. Concerning the last, quality thresholds as well as bioinformatic settings (i.e., clustering approach, analysis pipeline, and specific adjustments such as truncation) are responsible for a number of observed...

    Isabel Abellan-Schneyder, Monica S. Matchado, Sandra Reitmeier, Alina Sommer, Zeno Sewald, Jan Baumbach, Markus List, Klaus Neuhaus
    24 Feb 2021

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