VPS retromer

  • Open Access
    A Role for the VPS Retromer in <em>Brucella</em> Intracellular Replication Revealed by Genomewide siRNA Screening
    Research Article | Host-Microbe Biology
    A Role for the VPS Retromer in Brucella Intracellular Replication Revealed by Genomewide siRNA Screening

    With >300,000 new cases of human brucellosis annually, Brucella is regarded as one of the most important zoonotic bacterial pathogens worldwide. The agent causing brucellosis resides inside host cells within vacuoles termed Brucella-containing vacuoles (BCVs). Although a few host components required to escape the degradative lysosomal pathway and to establish the ER-derived replicative BCV (rBCV) have already been...

    Alain Casanova, Shyan Huey Low, Maxime Québatte, Jaroslaw Sedzicki, Therese Tschon, Maren Ketterer, Kevin Smith, Mario Emmenlauer, Houchaima Ben-Tekaya, Christoph Dehio
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