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Vibrio cholerae

  • Open Access
    Suppressor Mutations in Type II Secretion Mutants of <span class="named-content genus-species" id="named-content-1">Vibrio cholerae</span>: Inactivation of the VesC Protease
    Research Article | Molecular Biology and Physiology
    Suppressor Mutations in Type II Secretion Mutants of Vibrio cholerae: Inactivation of the VesC Protease

    Genome-wide transposon mutagenesis has identified the genes encoding the T2SS in Vibrio cholerae as essential for viability, but the reason for this is unclear. Mutants with deletions or insertions in these genes can be isolated, suggesting that they have acquired secondary mutations that suppress their growth defect.

    Chelsea S. Rule, Young-Jun Park, Jaclyn R. Delarosa, Stewart Turley, Wim G. J. Hol, Sarah McColm, Colby Gura, Frank DiMaio, Konstantin V. Korotkov, Maria Sandkvist
  • Open Access
    TsrA Regulates Virulence and Intestinal Colonization in <em>Vibrio cholerae</em>
    Research Article | Molecular Biology and Physiology
    TsrA Regulates Virulence and Intestinal Colonization in Vibrio cholerae

    Cholera is a potentially lethal disease that is endemic in much of the developing world. Vibrio cholerae, the bacterium underlying the disease, infects humans utilizing proteins encoded on horizontally acquired genetic material. Here, we provide evidence that TsrA, a Vibrionaceae-specific protein, plays a critical role in regulating these genetic elements and...

    Cory D. DuPai, Ashley L. Cunningham, Aaron R. Conrado, Claus O. Wilke, Bryan W. Davies
  • Open Access
    Identification of Spacer and Protospacer Sequence Requirements in the <span class="named-content genus-species" id="named-content-1">Vibrio cholerae</span> Type I-E CRISPR/Cas System
    Research Article | Molecular Biology and Physiology
    Identification of Spacer and Protospacer Sequence Requirements in the Vibrio cholerae Type I-E CRISPR/Cas System

    Bacterial CRISPR/Cas systems provide immunity by defending against phage and other invading elements. A thorough comprehension of the molecular mechanisms employed by these diverse systems will improve our understanding of bacteriophage-bacterium interactions and bacterial adaptation to foreign DNA. The Vibrio cholerae type I-E system was previously identified in an...

    Jacob Bourgeois, David W. Lazinski, Andrew Camilli
  • Open Access
    Prophage-Dependent Neighbor Predation Fosters Horizontal Gene Transfer by Natural Transformation
    Observation | Ecological and Evolutionary Science
    Prophage-Dependent Neighbor Predation Fosters Horizontal Gene Transfer by Natural Transformation

    Prophages are nearly ubiquitous in bacterial species. These integrated phage elements have previously been implicated in horizontal gene transfer (HGT) largely through their ability to carry out transduction (generalized or specialized). Here, we show that prophage-encoded viral particles promote neighbor predation leading to enhanced HGT by natural transformation in the waterborne pathogen...

    Roberto C. Molina-Quiroz, Triana N. Dalia, Andrew Camilli, Ankur B. Dalia, Cecilia A. Silva-Valenzuela
  • Open Access
    Antibiotic Resistance in <span class="named-content genus-species" id="named-content-1">Vibrio cholerae</span>: Mechanistic Insights from IncC Plasmid-Mediated Dissemination of a Novel Family of Genomic Islands Inserted at <em>trmE</em>
    Research Article | Molecular Biology and Physiology
    Antibiotic Resistance in Vibrio cholerae: Mechanistic Insights from IncC Plasmid-Mediated Dissemination of a Novel Family of Genomic Islands Inserted at trmE

    The increasing association of the etiological agent of cholera, Vibrio cholerae serogroup O1 and O139, with multiple antibiotic resistance threatens to deprive health practitioners of this effective tool. Drug resistance in cholera results mainly from acquisition of mobile genetic elements. Genomic islands conferring multidrug resistance and mobilizable by IncC...

    Nicolas Rivard, Rita R. Colwell, Vincent Burrus
  • Open Access
    <em>Vibrio cholerae</em> at the Intersection of Immunity and the Microbiome
    Minireview | Host-Microbe Biology
    Vibrio cholerae at the Intersection of Immunity and the Microbiome

    Vibrio cholerae is a noninvasive pathogen that colonizes the small intestine and produces cholera toxin, causing severe secretory diarrhea. Cholera results in long lasting immunity, and recent studies have improved our understanding of the antigenic repertoire of V. cholerae. Interactions between...

    Ana A. Weil, Rachel L. Becker, Jason B. Harris
  • Open Access
    Posttranslational Regulation of IL-23 Production Distinguishes the Innate Immune Responses to Live Toxigenic versus Heat-Inactivated <span class="named-content genus-species" id="named-content-1">Vibrio cholerae</span>
    Research Article | Molecular Biology and Physiology
    Posttranslational Regulation of IL-23 Production Distinguishes the Innate Immune Responses to Live Toxigenic versus Heat-Inactivated Vibrio cholerae

    An episode of cholera provides better protection against reinfection than oral cholera vaccines, and the reasons for this are still under study. To better understand this, we compared the immune responses of human cells exposed to live Vibrio cholerae with those of cells exposed to heat-killed V. cholerae...

    Ana A. Weil, Crystal N. Ellis, Meti D. Debela, Taufiqur R. Bhuiyan, Rasheduzzaman Rashu, Daniel L. Bourque, Ashraful I. Khan, Fahima Chowdhury, Regina C. LaRocque, Richelle C. Charles, Edward T. Ryan, Stephen B. Calderwood, Firdausi Qadri, Jason B. Harris
  • Open Access
    Unsupervised Learning Approach for Comparing Multiple Transposon Insertion Sequencing Studies
    Research Article | Host-Microbe Biology
    Unsupervised Learning Approach for Comparing Multiple Transposon Insertion Sequencing Studies

    Forward genetic screens are powerful tools for functional genomics. The comparison of similar forward genetic screens performed in different organisms enables the identification of genes with similar or different phenotypes across organisms. Transposon insertion sequencing is a widely used method for conducting genome-scale forward genetic screens in bacteria, yet few bioinformatic approaches have been developed to compare the results...

    Troy P. Hubbard, Jonathan D. D’Gama, Gabriel Billings, Brigid M. Davis, Matthew K. Waldor
  • Open Access
    Sublingual Adjuvant Delivery by a Live Attenuated <span class="named-content genus-species" id="named-content-1">Vibrio cholerae</span>-Based Antigen Presentation Platform
    Research Article | Therapeutics and Prevention
    Sublingual Adjuvant Delivery by a Live Attenuated Vibrio cholerae-Based Antigen Presentation Platform

    Diarrheal disease is the most common infectious disease of children in the developing world. Our goal is to develop a diarrheal antigen presentation platform based on whole Vibrio cholerae cells that does not depend on protein purification. We have previously shown the feasibility of genetically fusing antigens to the...

    Julie Liao, Jacob A. Gibson, Bradley S. Pickering, Paula I. Watnick
  • Open Access
    <em>In Situ</em> Analyses Directly in Diarrheal Stool Reveal Large Variations in Bacterial Load and Active Toxin Expression of Enterotoxigenic <span class="named-content genus-species" id="named-content-1">Escherichia coli</span> and <span class="named-content genus-species" id="named-content-2">Vibrio cholerae</span>
    Research Article | Host-Microbe Biology
    In Situ Analyses Directly in Diarrheal Stool Reveal Large Variations in Bacterial Load and Active Toxin Expression of Enterotoxigenic Escherichia coli and Vibrio cholerae

    The cause of diarrheal disease is usually determined by screening for several microorganisms by various methods, and sole detection is used to assign the agent as the cause of disease. However, it has become increasingly clear that many infections are caused by coinfections with several pathogens and that the dose of the infecting pathogen is important. We quantified the absolute numbers of enterotoxigenic...

    Yasmin Ara Begum, Hanna A. Rydberg, Kaisa Thorell, Young-Keun Kwak, Lei Sun, Enrique Joffré, Firdausi Qadri, Åsa Sjöling

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