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transcriptional regulation

  • Open Access
    Mapping the Global Network of Extracellular Protease Regulation in <span class="named-content genus-species" id="named-content-1">Staphylococcus aureus</span>
    Research Article | Molecular Biology and Physiology
    Mapping the Global Network of Extracellular Protease Regulation in Staphylococcus aureus

    The complex regulatory role of the proteases necessitates very tight coordination and control of their expression. While this process has been well studied, a major oversight has been the consideration of proteases as a single entity rather than as 10 enzymes produced from four different promoters. As such, in this study, we comprehensively characterized the regulation of each protease promoter, discovering vast differences in the way...

    Brittney D. Gimza, Maria I. Larias, Bridget G. Budny, Lindsey N. Shaw
  • Open Access
    Functional Characterization of <span class="named-content genus-species" id="named-content-1">Entamoeba histolytica</span> Argonaute Proteins Reveals a Repetitive DR-Rich Motif Region That Controls Nuclear Localization
    Research Article | Host-Microbe Biology
    Functional Characterization of Entamoeba histolytica Argonaute Proteins Reveals a Repetitive DR-Rich Motif Region That Controls Nuclear Localization

    The protozoan parasite Entamoeba histolytica, which causes amebiasis and affects over 50 million people worldwide, contains an important RNAi pathway for gene silencing. Gene silencing via the RNAi pathway is mediated by the Argonaute (Ago) proteins. However, we lack knowledge on Ago function(s) in this nonmodel system. In this paper, we discovered that three...

    Hanbang Zhang, Vy Tran, Dipak Manna, Gretchen Ehrenkaufer, Upinder Singh
  • Open Access
    Plasmids for Independently Tunable, Low-Noise Expression of Two Genes
    Resource Report | Synthetic Biology
    Plasmids for Independently Tunable, Low-Noise Expression of Two Genes

    Microbiologists often express foreign proteins in bacteria in order study them or to use bacteria as a microbial factory. Usually, this requires controlling the number of foreign proteins expressed in each cell, but for many common protein expression systems, it is difficult to “tune” protein expression without large cell-to-cell variation in expression levels (called “noise” in protein expression). This work describes two protein...

    João P. N. Silva, Soraia Vidigal Lopes, Diogo J. Grilo, Zach Hensel
  • Open Access
    Multiple Evolutionarily Conserved Domains of Cap2 Are Required for Promoter Recruitment and Iron Homeostasis Gene Regulation
    Research Article | Molecular Biology and Physiology
    Multiple Evolutionarily Conserved Domains of Cap2 Are Required for Promoter Recruitment and Iron Homeostasis Gene Regulation

    Iron is an essential micronutrient for living cells. Candida albicans, the predominant human fungal pathogen, thrives under diverse environments with vastly different iron levels in the mammalian host. Therefore, to tightly control iron homeostasis, C. albicans has evolved a set of transcriptional...

    Manjit Kumar Srivastav, Neha Agarwal, Krishnamurthy Natarajan
  • Open Access
    Construction and Use of a Recyclable Marker To Examine the Role of Major Facilitator Superfamily Protein Members in <span class="named-content genus-species" id="named-content-1">Candida glabrata</span> Drug Resistance Phenotypes
    Editor's Pick Research Article | Molecular Biology and Physiology
    Construction and Use of a Recyclable Marker To Examine the Role of Major Facilitator Superfamily Protein Members in Candida glabrata Drug Resistance Phenotypes

    Export of drugs is a problem for chemotherapy of infectious organisms. A class of membrane proteins called the major facilitator superfamily contains a large number of proteins that often elevate drug resistance when overproduced but do not impact this phenotype when the gene is removed. We wondered if this absence of a phenotype for a disruption allele might be due to the redundancy of this group of membrane proteins. We describe the...

    Bao G. Vu, W. Scott Moye-Rowley
  • Open Access
    Transcriptional Regulation of Carnitine Catabolism in <span class="named-content genus-species" id="named-content-1">Pseudomonas aeruginosa</span> by CdhR
    Research Article | Molecular Biology and Physiology
    Transcriptional Regulation of Carnitine Catabolism in Pseudomonas aeruginosa by CdhR

    Pathogens must metabolize host-derived compounds during infection and properly regulate the responsible pathways. Carnitine is a common eukaryotic-associated quaternary amine compound that can be catabolized by Pseudomonas aeruginosa. Here we expand on our understanding of how this metabolic pathway is regulated and provide details on how carnitine catabolism is...

    Jamie A. Meadows, Matthew J. Wargo
  • Open Access
    Plasticity of the <em>MFS1</em> Promoter Leads to Multidrug Resistance in the Wheat Pathogen <em>Zymoseptoria tritici</em>
    Research Article | Applied and Environmental Science
    Plasticity of the MFS1 Promoter Leads to Multidrug Resistance in the Wheat Pathogen Zymoseptoria tritici

    Disease control through fungicides remains an important means to protect crops from fungal diseases and to secure the harvest. Plant-pathogenic fungi, especially Zymoseptoria tritici, have developed resistance against most currently used active ingredients, reducing or abolishing their efficacy. While target site modification is the most common resistance mechanism against single modes of action, active efflux of multiple drugs...

    Selim Omrane, Colette Audéon, Amandine Ignace, Clémentine Duplaix, Lamia Aouini, Gert Kema, Anne-Sophie Walker, Sabine Fillinger
  • Open Access
    A Quorum-Sensing System That Regulates <span class="named-content genus-species" id="named-content-1">Streptococcus pneumoniae</span> Biofilm Formation and Surface Polysaccharide Production
    Research Article | Molecular Biology and Physiology
    A Quorum-Sensing System That Regulates Streptococcus pneumoniae Biofilm Formation and Surface Polysaccharide Production

    Quorum sensing regulates bacterial social behaviors by production, secretion, and sensing of pheromones. In this study, we characterized a new quorum-sensing system of the Rgg/SHP class in S. pneumoniae D39. The system was found to directly induce the expression of a single gene cluster comprising the gene for the SHP pheromone and genes with putative functions in...

    Roger Junges, Gabriela Salvadori, Sudhanshu Shekhar, Heidi A. Åmdal, Jimstan N. Periselneris, Tsute Chen, Jeremy S. Brown, Fernanda C. Petersen
  • Open Access
    Grf10 and Bas1 Regulate Transcription of Adenylate and One-Carbon Biosynthesis Genes and Affect Virulence in the Human Fungal Pathogen <span class="named-content genus-species" id="named-content-1">Candida albicans</span>
    Research Article | Molecular Biology and Physiology
    Grf10 and Bas1 Regulate Transcription of Adenylate and One-Carbon Biosynthesis Genes and Affect Virulence in the Human Fungal Pathogen Candida albicans

    Candida albicans is a commensal and a common constituent of the human microbiota; however, it can become pathogenic and cause infections in both immunocompetent and immunocompromised people. C. albicans exhibits remarkable metabolic versatility as it can colonize multiple body sites as a commensal...

    Tanaporn Wangsanut, Anup K. Ghosh, Peter G. Metzger, William A. Fonzi, Ronda J. Rolfes
  • Open Access
    Reconfiguration of Transcriptional Control of Lysine Biosynthesis in <span class="named-content genus-species" id="named-content-1">Candida albicans</span> Involves a Central Role for the Gcn4 Transcriptional Activator
    Editor's Pick Research Article | Molecular Biology and Physiology
    Reconfiguration of Transcriptional Control of Lysine Biosynthesis in Candida albicans Involves a Central Role for the Gcn4 Transcriptional Activator

    Microbes evolve rapidly so as to reconfigure their gene expression to adapt to the metabolic demands in diverse environmental niches. Here, we explored how conditions of nutrient deprivation regulate lysine biosynthesis in the human fungal pathogen Candida albicans. We show that although both Saccharomyces...

    Yumnam Priyadarshini, Krishnamurthy Natarajan
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