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transcription factors

  • Open Access
    Phosphoproteomics of <span class="named-content genus-species" id="named-content-1">Aspergillus fumigatus</span> Exposed to the Antifungal Drug Caspofungin
    Research Article | Molecular Biology and Physiology
    Phosphoproteomics of Aspergillus fumigatus Exposed to the Antifungal Drug Caspofungin

    Aspergillus fumigatus is an opportunistic human-pathogenic fungus causing allergic reactions or systemic infections, such as invasive pulmonary aspergillosis in immunocompromised patients. Caspofungin is an echinocandin that impacts the construction of the fungal cell wall by inhibiting the biosynthesis of the β-1,3-glucan polysaccharide. Caspofungin is a fungistatic...

    Eliciane Cevolani Mattos, Giuseppe Palmisano, Gustavo H. Goldman
  • Open Access
    mSphere of Influence: Decoding Transcriptional Regulatory Networks To Illuminate the Mechanisms of Microbial Pathogenicity
    Commentary | Host-Microbe Biology
    mSphere of Influence: Decoding Transcriptional Regulatory Networks To Illuminate the Mechanisms of Microbial Pathogenicity

    Sadri Znaidi works in the field of molecular mycology with a focus on functional genomics in Candida albicans. In this mSphere of Influence article, he reflects on how the paper “An iron homeostasis regulatory circuit with reciprocal roles in Candida albicans commensalism and pathogenesis” by Chen...

    Sadri Znaidi
  • Open Access
    Weak Acid Resistance A (WarA), a Novel Transcription Factor Required for Regulation of Weak-Acid Resistance and Spore-Spore Heterogeneity in <span class="named-content genus-species" id="named-content-1">Aspergillus niger</span>
    Research Article | Molecular Biology and Physiology
    Weak Acid Resistance A (WarA), a Novel Transcription Factor Required for Regulation of Weak-Acid Resistance and Spore-Spore Heterogeneity in Aspergillus niger

    Weak acids are widely used as food preservatives, as they are very effective at preventing the growth of most species of bacteria and fungi. However, some species of molds can survive and grow in the concentrations of weak acid employed in food and drink products, thereby causing spoilage with resultant risks for food security and health. Current knowledge of weak-acid resistance mechanisms in these fungi is limited, especially in...

    Ivey A. Geoghegan, Malcolm Stratford, Mike Bromley, David B. Archer, Simon V. Avery
  • Open Access
    Functional Mapping of Transcription Factor Grf10 That Regulates Adenine-Responsive and Filamentation Genes in <span class="named-content genus-species" id="named-content-1">Candida albicans</span>
    Research Article | Molecular Biology and Physiology
    Functional Mapping of Transcription Factor Grf10 That Regulates Adenine-Responsive and Filamentation Genes in Candida albicans

    Metabolic adaptation and morphogenesis are essential for Candida albicans, a major human fungal pathogen, to survive and infect diverse body sites in the mammalian host. C. albicans utilizes transcription factors to tightly control the transcription of metabolic genes and morphogenesis genes. Grf10...

    Tanaporn Wangsanut, Joshua M. Tobin, Ronda J. Rolfes
  • Open Access
    Opposing Transcriptional Mechanisms Regulate <em>Toxoplasma</em> Development
    Editor's Pick Research Article | Molecular Biology and Physiology
    Opposing Transcriptional Mechanisms Regulate Toxoplasma Development

    Toxoplasma infections are lifelong because of the development of the bradyzoite tissue cyst, which is effectively invisible to the immune system. Despite the important clinical consequences of this developmental pathway, the molecular basis of the switch mechanisms that control tissue cyst formation is still poorly understood. Significant changes in gene expression are associated with tissue cyst development, and ApiAP2...

    Dong-Pyo Hong, Joshua B. Radke, Michael W. White
  • Open Access
    GcsR, a TyrR-Like Enhancer-Binding Protein, Regulates Expression of the Glycine Cleavage System in <span class="named-content genus-species" id="named-content-1">Pseudomonas aeruginosa</span> PAO1
    Research Article | Molecular Biology and Physiology
    GcsR, a TyrR-Like Enhancer-Binding Protein, Regulates Expression of the Glycine Cleavage System in Pseudomonas aeruginosa PAO1

    Glycine is required for various cellular functions, including cell wall synthesis, protein synthesis, and the biosynthesis of several important metabolites. Regulating levels of glycine metabolism allows P. aeruginosa to maintain the metabolic flux of glycine through several pathways, including the metabolism of glycine to produce other amino acids, entry into the...

    Zaara Sarwar, Benjamin R. Lundgren, Michael T. Grassa, Michael X. Wang, Megan Gribble, Jennifer F. Moffat, Christopher T. Nomura
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