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    • Archive
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Toxoplasma

  • Open Access
    CRISPR/Cas9-Based Knockout of GNAQ Reveals Differences in Host Cell Signaling Necessary for Egress of Apicomplexan Parasites
    Observation | Host-Microbe Biology
    CRISPR/Cas9-Based Knockout of GNAQ Reveals Differences in Host Cell Signaling Necessary for Egress of Apicomplexan Parasites

    The coordinated release of apicomplexan parasites from infected host cells prior to reinvasion is a critical process for parasite survival and the spread of infection. While Toxoplasma tachyzoites and Plasmodium blood stages induce a fast disruption of their surrounding membranes during their egress from host cells, Plasmodium liver stages keep the host cell membrane intact and leave their host cell in host...

    Paul-Christian Burda, Hugo Bisio, Jean-Baptiste Marq, Dominique Soldati-Favre, Volker T. Heussler
  • Open Access
    <span class="named-content genus-species" id="named-content-1">Toxoplasma gondii</span> AP2XII-2 Contributes to Proper Progression through S-Phase of the Cell Cycle
    Research Article | Molecular Biology and Physiology
    Toxoplasma gondii AP2XII-2 Contributes to Proper Progression through S-Phase of the Cell Cycle

    Toxoplasma gondii is a single-celled parasite that persists in its host by converting into a latent cyst stage. This work describes a new transcriptional factor called AP2XII-2 that plays a role in properly maintaining the growth rate of replicating parasites, which contributes to signals required for development into its dormant stage. Without AP2XII-2, ...

    Sandeep Srivastava, Michael W. White, William J. Sullivan
  • Open Access
    The Secreted Acid Phosphatase Domain-Containing GRA44 from <span class="named-content genus-species" id="named-content-1">Toxoplasma gondii</span> Is Required for c-Myc Induction in Infected Cells
    Editor's Pick Research Article | Host-Microbe Biology
    The Secreted Acid Phosphatase Domain-Containing GRA44 from Toxoplasma gondii Is Required for c-Myc Induction in Infected Cells

    Approximately one-third of humans are infected with the parasite Toxoplasma gondii. Toxoplasma infections can lead to severe disease in those with a compromised or suppressed immune system. Additionally, infections during pregnancy present a significant health risk to the developing fetus. Drugs that target this parasite are limited, have significant side...

    William J. Blakely, Michael J. Holmes, Gustavo Arrizabalaga
  • Open Access
    Coimmunoprecipitation with MYR1 Identifies Three Additional Proteins within the <span class="named-content genus-species" id="named-content-1">Toxoplasma gondii</span> Parasitophorous Vacuole Required for Translocation of Dense Granule Effectors into Host Cells
    Editor's Pick Research Article | Host-Microbe Biology
    Coimmunoprecipitation with MYR1 Identifies Three Additional Proteins within the Toxoplasma gondii Parasitophorous Vacuole Required for Translocation of Dense Granule Effectors into Host Cells

    Toxoplasma is an extremely successful intracellular parasite and important human pathogen. Upon infection of a new cell, Toxoplasma establishes a replicative vacuole and translocates parasite effectors across this vacuole to function from the host cytosol and nucleus. These effectors play a key role in parasite virulence. The work reported here newly identifies three parasite proteins that are necessary for protein...

    Alicja M. Cygan, Terence C. Theisen, Alma G. Mendoza, Nicole D. Marino, Michael W. Panas, John C. Boothroyd
  • Open Access
    mSphere of Influence: Ushering in the CRISPR Revolution to <em>Toxoplasma</em> Biology
    Commentary | Molecular Biology and Physiology
    mSphere of Influence: Ushering in the CRISPR Revolution to Toxoplasma Biology

    Alfredo J. Guerra works in the field of molecular parasitology and structural biology. In this mSphere of Influence article, he reflects on how “Efficient Gene Disruption in Diverse Strains of Toxoplasma gondii Using CRISPR/CAS9” by Bang Shen et al. (mBio 5:e01114-14, 2014, https://doi.org/10.1128/mBio.01114-14) and...

    Alfredo J. Guerra
  • Open Access
    Simultaneous Ribosome Profiling of Human Host Cells Infected with <span class="named-content genus-species" id="named-content-1">Toxoplasma gondii</span>
    Research Article | Host-Microbe Biology
    Simultaneous Ribosome Profiling of Human Host Cells Infected with Toxoplasma gondii

    Toxoplasma gondii is a single-celled parasite that has infected up to one-third of the world’s population. Significant overhauls in gene expression in both the parasite and the host cell accompany parasite invasion, and a better understanding of these changes may lead to the development of new therapeutic agents. In this study, we employed ribosome profiling to...

    Michael J. Holmes, Premal Shah, Ronald C. Wek, William J. Sullivan
  • Open Access
    Differential Roles for Inner Membrane Complex Proteins across <span class="named-content genus-species" id="named-content-1">Toxoplasma gondii</span> and <em>Sarcocystis neurona</em> Development
    Research Article | Host-Microbe Biology
    Differential Roles for Inner Membrane Complex Proteins across Toxoplasma gondii and Sarcocystis neurona Development

    The inner membrane complex (IMC) is a defining feature of apicomplexan parasites key to both their motility and unique cell division. To provide further insights into the IMC, we analyzed the dynamics and functions of representative alveolin domain-containing IMC proteins across developmental stages. Our work shows universal but distinct roles for IMC1, -3, and -7 during Toxoplasma asexual division but more specialized...

    Rashmi Dubey, Brooke Harrison, Sriveny Dangoudoubiyam, Giulia Bandini, Katherine Cheng, Aziz Kosber, Carolina Agop-Nersesian, Daniel K. Howe, John Samuelson, David J. P. Ferguson, Marc-Jan Gubbels
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