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Staphylococcus

  • Open Access
    Staphylococcal Protein A (<em>spa</em>) Locus Is a Hot Spot for Recombination and Horizontal Gene Transfer in <span class="named-content genus-species" id="named-content-1">Staphylococcus pseudintermedius</span>
    Research Article | Ecological and Evolutionary Science
    Staphylococcal Protein A (spa) Locus Is a Hot Spot for Recombination and Horizontal Gene Transfer in Staphylococcus pseudintermedius

    Staphylococcus pseudintermedius is a major canine pathogen but can also occasionally infect humans. Identification of genetic factors contributing to the virulence and clonal success of multidrug-resistant S. pseudintermedius clones is critical for the development of therapeutics against this...

    Alem Zukancic, Mubin A. Khan, Sumayya J. Gurmen, Quinn M. Gliniecki, Dayna L. Moritz-Kinkade, Carol W. Maddox, Md Tauqeer Alam
  • Open Access
    <span class="named-content genus-species" id="named-content-1">Candida albicans</span> Impacts <span class="named-content genus-species" id="named-content-2">Staphylococcus aureus</span> Alpha-Toxin Production via Extracellular Alkalinization
    Research Article | Host-Microbe Biology
    Candida albicans Impacts Staphylococcus aureus Alpha-Toxin Production via Extracellular Alkalinization

    Candida albicans and Staphylococcus aureus are commonly coisolated from central venous catheters and deep-seated infections, including intra-abdominal sepsis. Thus, they represent a significant cause of nosocomial morbidity and mortality. Yet how these organisms behave in the context of...

    Olivia A. Todd, Mairi C. Noverr, Brian M. Peters
  • Open Access
    <span class="named-content genus-species" id="named-content-1">Staphylococcus aureus</span> Coproporphyrinogen III Oxidase Is Required for Aerobic and Anaerobic Heme Synthesis
    Observation | Molecular Biology and Physiology
    Staphylococcus aureus Coproporphyrinogen III Oxidase Is Required for Aerobic and Anaerobic Heme Synthesis

    Heme is a critical molecule required for aerobic and anaerobic respiration by organisms across kingdoms. The human pathogen Staphylococcus aureus has served as a model organism for the study of heme synthesis and heme-dependent physiology and, like many species of the phyla Firmicutes and Actinobacteria, generates heme through a coproporphyrin...

    Jacob E. Choby, Eric P. Skaar
  • Open Access
    A Novel <em>Staphylococcus</em> Podophage Encodes a Unique Lysin with Unusual Modular Design
    Observation | Therapeutics and Prevention
    A Novel Staphylococcus Podophage Encodes a Unique Lysin with Unusual Modular Design

    The spread of antibiotic resistance among bacterial pathogens is inciting a global public health crisis. Drug-resistant Staphylococcus species, especially S. aureus and S. epidermidis, have emerged in both hospital and community settings, underscoring the urgent need for new strategies to...

    Katie Cater, Vidya Sree Dandu, S. M. Nayeemul Bari, Kim Lackey, Gabriel F. K. Everett, Asma Hatoum-Aslan
  • Open Access
    Divergent Isoprenoid Biosynthesis Pathways in <em>Staphylococcus</em> Species Constitute a Drug Target for Treating Infections in Companion Animals
    Research Article | Therapeutics and Prevention
    Divergent Isoprenoid Biosynthesis Pathways in Staphylococcus Species Constitute a Drug Target for Treating Infections in Companion Animals

    Drug-resistant Staphylococcus species are a major concern in human and veterinary medicine. There is a need for new antibiotics that exhibit a selective effect in treating infections in companion and livestock animals and that would not be used to treat human bacterial infections. We have identified fosmidomycin as an antibiotic that selectively targets certain Staphylococcus species that are often encountered in skin...

    Ana M. Misic, Christine L. Cain, Daniel O. Morris, Shelley C. Rankin, Daniel P. Beiting
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