SARS-CoV-2
Editor's Pick Research ArticleEvaluating the Antimicrobial Properties of Commercial Hand SanitizersIn response to the coronavirus disease 2019 (COVID-19) pandemic, hand hygiene has taken on a prominent role in efforts to mitigate SARS-CoV-2 transmission and infection, which has led to a radical increase in the number and types of hand sanitizers manufactured to meet public demand. To our knowledge, no studies have evaluated or compared the antimicrobial performance of hand sanitizers that are being produced under COVID-19 emergency...
Research ArticleAntibody Response against SARS-CoV-2 and Seasonal Coronaviruses in Nonhospitalized COVID-19 PatientsThere is strong interest in the nature of the neutralizing antibody response against SARS-CoV-2 in infected individuals. For vaccine development, it is especially important which antibodies confer protection against SARS-CoV-2, if there is a phenomenon called antibody-dependent enhancement (ADE) of infection, and if there is cross-protection by antibodies directed against seasonal coronaviruses.
Research Article | Clinical Science and EpidemiologyMolecular Evolution of Human Coronavirus 229E in Hong Kong and a Fatal COVID-19 Case Involving Coinfection with a Novel Human Coronavirus 229E GenogroupSince its first appearance in the 1960s, the genetic diversity and evolution of human coronavirus 229E (HCoV-229E) have been relatively understudied. In this study, we report a fatal case of COVID-19 coinfected with HCoV-229E in Hong Kong.
Research Article | Clinical Science and EpidemiologySeroprevalence of SARS-CoV-2 Antibodies in Children and Adults in St. Louis, Missouri, USAThis study determined the percentages of both children and adult samples from the greater St. Louis metropolitan area who had antibodies to SARS-CoV-2 in late April to early May 2020.
Research Article | Clinical Science and EpidemiologyInterplay of Antibody and Cytokine Production Reveals CXCL13 as a Potential Novel Biomarker of Lethal SARS-CoV-2 InfectionThe SARS-CoV-2 pandemic is continuing to impact the global population, and knowledge of the immune response to COVID-19 is still developing. This study assesses the interplay of different parts of the immune system during COVID-19 disease.
Observation | Clinical Science and EpidemiologyAn Observational Laboratory-Based Assessment of SARS-CoV-2 Molecular Diagnostics in Benin, Western AfricaMonths after the start of the COVID-19 pandemic, case numbers from Africa are surprisingly low, potentially because the number of SARS-CoV-2 tests performed in Africa is lower than in other regions. Here, we show an overload of COVID-19-related diagnostics in the central laboratory of Benin, Western Africa, with a stagnating average number of positive samples irrespective of daily sample counts.
Research Article | Clinical Science and EpidemiologyMonitoring COVID-19 Transmission Risks by Quantitative Real-Time PCR Tracing of Droplets in Hospital and Living EnvironmentsSeveral studies evaluated the presence of SARS-CoV-2 in the environment. Saliva and nasopharyngeal droplets can land on objects and surfaces, creating fomites.
Research Article | Clinical Science and EpidemiologyConserved Genomic Terminals of SARS-CoV-2 as Coevolving Functional Elements and Potential Therapeutic TargetsThe CoV disease 2019 (COVID-19) infectious disease outbreak is having a dramatic global effect on public health and the economy. As of October 2020, SARS-CoV-2 has been detected in over 189 countries, has infected over 40 million people, and is responsible for more than 1 million deaths.
Research Article | Clinical Science and EpidemiologyDaily Viral Kinetics and Innate and Adaptive Immune Response Assessment in COVID-19: a Case SeriesThis work is particularly important because it simultaneously assessed the virology, immunology, and clinical presentation of the same subjects, whereas other studies assess these separately. We describe the detailed viral and immune profiles of the first five patients infected by SARS-CoV-2 and quarantined in Geneva, Switzerland. Viral loads peaked at the very beginning of the disease, and infectious virus was shed only during the...
Research Article | Clinical Science and EpidemiologyA Genome Epidemiological Study of SARS-CoV-2 Introduction into JapanThis study aimed to evaluate the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) genome sequences from COVID-19 cases and to characterize their genealogical networks to demonstrate possible routes of spread in Japan. We found that there were at least two distinct SARS-CoV-2 introductions into Japan, initially from China and subsequently from other countries, including Europe. Our findings can help understand how SARS-CoV-2...