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Pseudomonas aeruginosa

  • Open Access
    Ceftolozane/Tazobactam Resistance and Mechanisms in Carbapenem-Nonsusceptible <span class="named-content genus-species" id="named-content-1">Pseudomonas aeruginosa</span>
    Research Article | Clinical Science and Epidemiology
    Ceftolozane/Tazobactam Resistance and Mechanisms in Carbapenem-Nonsusceptible Pseudomonas aeruginosa

    Pseudomonas aeruginosa infection is one of the most difficult health care-associated infections to treat due to the ability of the organism to acquire a multitude of resistance mechanisms and express the multidrug resistance phenotype. Ceftolozane/tazobactam (C/T), a novel β-lactam/β-lactamase inhibitor combination, addresses an unmet medical need in...

    Jocelyn Qi-Min Teo, Jie Chong Lim, Cheng Yee Tang, Shannon Jing-Yi Lee, Si Hui Tan, James Heng-Chiak Sim, Rick Twee-Hee Ong, Andrea Lay-Hoon Kwa
  • Open Access
    Phenotypic and Genotypic Adaptations in <span class="named-content genus-species" id="named-content-1">Pseudomonas aeruginosa</span> Biofilms following Long-Term Exposure to an Alginate Oligomer Therapy
    Research Article | Therapeutics and Prevention
    Phenotypic and Genotypic Adaptations in Pseudomonas aeruginosa Biofilms following Long-Term Exposure to an Alginate Oligomer Therapy

    The emergence of multidrug-resistant (MDR) pathogens within biofilms in the cystic fibrosis lung results in increased morbidity. An inhalation therapy derived from alginate, OligoG CF-5/20, is currently in clinical trials for cystic fibrosis patients.

    Juliette L. Oakley, Rebecca Weiser, Lydia C. Powell, Julian Forton, Eshwar Mahenthiralingam, Philip D. Rye, Katja E. Hill, David W. Thomas, Manon F. Pritchard
  • Open Access
    A Novel N4-Like Bacteriophage Isolated from a Wastewater Source in South India with Activity against Several Multidrug-Resistant Clinical <span class="named-content genus-species" id="named-content-1">Pseudomonas aeruginosa</span> Isolates
    Research Article | Clinical Science and Epidemiology
    A Novel N4-Like Bacteriophage Isolated from a Wastewater Source in South India with Activity against Several Multidrug-Resistant Clinical Pseudomonas aeruginosa Isolates

    In India, multidrug resistance determinants are much more abundant in community-associated bacterial pathogens due to the improper treatment of domestic and industrial effluents. In particular, a high bacterial load of the opportunistic pathogen P. aeruginosa in sewage and water bodies in India is well documented.

    Nitasha D. Menon, Megha S. Kumar, T. G. Satheesh Babu, Sucharita Bose, Gayathri Vijayakumar, Manasi Baswe, Meghna Chatterjee, Jovita Rowena D’Silva, Kavya Shetty, Jayalekshmi Haripriyan, Anil Kumar, Samitha Nair, Priyanka Somanath, Bipin G. Nair, Victor Nizet, Geetha B. Kumar
  • Open Access
    The Two-Component System CopRS Maintains Subfemtomolar Levels of Free Copper in the Periplasm of <span class="named-content genus-species" id="named-content-1">Pseudomonas aeruginosa</span> Using a Phosphatase-Based Mechanism
    Research Article | Molecular Biology and Physiology
    The Two-Component System CopRS Maintains Subfemtomolar Levels of Free Copper in the Periplasm of Pseudomonas aeruginosa Using a Phosphatase-Based Mechanism

    Copper is a micronutrient required as cofactor in redox enzymes. When free, copper is toxic, mismetallating proteins and generating damaging free radicals.

    Lorena Novoa-Aponte, Cheng Xu, Fernando C. Soncini, José M. Argüello
  • Open Access
    <em>Pseudomonas</em> Quinolone Signal-Induced Outer Membrane Vesicles Enhance Biofilm Dispersion in <span class="named-content genus-species" id="named-content-1">Pseudomonas aeruginosa</span>
    Research Article | Molecular Biology and Physiology
    Pseudomonas Quinolone Signal-Induced Outer Membrane Vesicles Enhance Biofilm Dispersion in Pseudomonas aeruginosa

    Treatments that manipulate biofilm dispersion hold the potential to convert chronic drug-tolerant biofilm infections from protected sessile communities into released populations that are orders-of-magnitude more susceptible to antimicrobial treatment. However, dispersed cells often exhibit increased acute virulence and dissemination phenotypes.

    Adam C. Cooke, Catalina Florez, Elise B. Dunshee, Avery D. Lieber, Michelle L. Terry, Caitlin J. Light, Jeffrey W. Schertzer
  • Open Access
    The Small RNA ErsA Plays a Role in the Regulatory Network of <span class="named-content genus-species" id="named-content-1">Pseudomonas aeruginosa</span> Pathogenicity in Airway Infections
    Research Article | Host-Microbe Biology
    The Small RNA ErsA Plays a Role in the Regulatory Network of Pseudomonas aeruginosa Pathogenicity in Airway Infections

    Pseudomonas aeruginosa is one of the most critical multidrug-resistant opportunistic pathogens in humans, able to cause both lethal acute and chronic lung infections. Thorough knowledge of the regulatory mechanisms involved in the establishment and persistence of the airways infections by P. aeruginosa...

    Silvia Ferrara, Alice Rossi, Serena Ranucci, Ida De Fino, Alessandra Bragonzi, Cristina Cigana, Giovanni Bertoni
  • Open Access
    <span class="named-content genus-species" id="named-content-1">Pseudomonas aeruginosa</span> Volatilome Characteristics and Adaptations in Chronic Cystic Fibrosis Lung Infections
    Research Article | Molecular Biology and Physiology
    Pseudomonas aeruginosa Volatilome Characteristics and Adaptations in Chronic Cystic Fibrosis Lung Infections

    Pseudomonas aeruginosa is a leading cause of chronic lung infections in cystic fibrosis (CF), which are correlated with lung function decline. Significant clinical efforts are therefore aimed at detecting infections and tracking them for phenotypic changes, such as mucoidy and antibiotic resistance. Both the detection and tracking of lung infections rely on sputum...

    Trenton J. Davis, Ava V. Karanjia, Charity N. Bhebhe, Sarah B. West, Matthew Richardson, Heather D. Bean
  • Open Access
    Alternating Dynamics of <em>oriC</em>, SMC, and MksBEF in Segregation of <span class="named-content genus-species" id="named-content-1">Pseudomonas aeruginosa</span> Chromosome
    Research Article | Molecular Biology and Physiology
    Alternating Dynamics of oriC, SMC, and MksBEF in Segregation of Pseudomonas aeruginosa Chromosome

    Mechanisms that define the chromosome as a structural entity remain unknown. Key elements in this process are condensins, which globally organize chromosomes and contribute to their segregation. This study characterized condensin and chromosome dynamics in Pseudomonas aeruginosa, which harbors condensins from two major protein superfamilies, SMC and MksBEF. The study...

    Hang Zhao, Bijit K. Bhowmik, Zoya M. Petrushenko, Valentin V. Rybenkov
  • Open Access
    Tracking of Antibiotic Resistance Transfer and Rapid Plasmid Evolution in a Hospital Setting by Nanopore Sequencing
    Research Article | Clinical Science and Epidemiology
    Tracking of Antibiotic Resistance Transfer and Rapid Plasmid Evolution in a Hospital Setting by Nanopore Sequencing

    Infections with multidrug-resistant bacteria represent a major threat to global health. While the spread of multidrug-resistant bacterial clones is frequently studied in the hospital setting, surveillance of the transfer of mobile genetic elements between different bacterial species was difficult until recent advances in sequencing technologies. Nanopore sequencing technology was applied to track antimicrobial gene transfer in a long-...

    Silke Peter, Mattia Bosio, Caspar Gross, Daniela Bezdan, Javier Gutierrez, Philipp Oberhettinger, Jan Liese, Wichard Vogel, Daniela Dörfel, Lennard Berger, Matthias Marschal, Matthias Willmann, Ivo Gut, Marta Gut, Ingo Autenrieth, Stephan Ossowski
  • Open Access
    Bacteria Modify <em>Candida albicans</em> Hypha Formation, Microcolony Properties, and Survival within Macrophages
    Research Article | Host-Microbe Biology
    Bacteria Modify Candida albicans Hypha Formation, Microcolony Properties, and Survival within Macrophages

    Candida albicans is the predominant fungus colonizing the oral cavity that can have both synergistic and antagonistic interactions with other bacteria. Interkingdom polymicrobial associations modify fungal pathogenicity and are believed to increase microbial resistance to innate immunity. However, it is not known how these interactions alter fungal survival during...

    Ornella Salvatori, Rohitashw Kumar, Sarah Metcalfe, Margaret Vickerman, Jason G. Kay, Mira Edgerton

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