Pseudomonas aeruginosa
Observation | Ecological and Evolutionary ScienceDisruption of Cross-Feeding Inhibits Pathogen Growth in the Sputa of Patients with Cystic FibrosisAntibiotic efficacy achieved in vitro correlates poorly with clinical outcomes after treatment of chronic polymicrobial diseases; if a pathogen demonstrates susceptibility to a given antibiotic in the lab, that compound is often ineffective when administered clinically. Conversely, if a pathogen is resistant in vitro, patient treatment with that same compound can elicit a positive response. This discordance suggests...
Commentary | Host-Microbe BiologymSphere of Influence: a Community To Study CommunitiesDominique Limoli studies polymicrobial interactions during cystic fibrosis respiratory disease. In this mSphere of Influence article, she reflects on how two papers (D. A. Hogan, S. D. Willger, E. L. Dolben, T. H. Hampton, et al., PLoS One 11:e0149998, 2016, https://doi.org/10.1371/journal.pone.0149998, and P. Jorth, B.
Research Article | Therapeutics and PreventionA Live Salmonella Vaccine Delivering PcrV through the Type III Secretion System Protects against Pseudomonas aeruginosaThe Gram-negative bacterium Pseudomonas aeruginosa is an important opportunistic pathogen that causes infections in cystic fibrosis and hospitalized patients. Therapeutic treatments are limited due to the emergence and spread of new antibiotic-resistant strains. In this context, the development of a vaccine is a priority. Here, we used an attenuated strain of...
Research Article | Molecular Biology and PhysiologyLoss of the Two-Component System TctD-TctE in Pseudomonas aeruginosa Affects Biofilm Formation and Aminoglycoside Susceptibility in Response to Citric AcidNutrient availability is an important contributor to the ability of bacteria to establish successful infections in a host. Pseudomonas aeruginosa is an opportunistic pathogen in humans causing infections that are difficult to treat. In part, its success is attributable to a high degree of metabolic versatility....
Research Article | Host-Microbe BiologyPseudomonas aeruginosa Protease IV Exacerbates Pneumococcal Pneumonia and Systemic DiseaseS. pneumoniae remains the leading cause of bacterial pneumonia despite widespread use of pneumococcal vaccines, forcing the necessity for appropriate treatment to control pneumococcal infections. Coinfections involving S. pneumoniae with other bacterial pathogens threaten antibiotic treatment...
Observation | Molecular Biology and PhysiologyTracking Polymicrobial Metabolism in Cystic Fibrosis Airways: Pseudomonas aeruginosa Metabolism and Physiology Are Influenced by Rothia mucilaginosa-Derived MetabolitesPseudomonas aeruginosa is a dominant and persistent cystic fibrosis pathogen. Although P. aeruginosa is accompanied by other microbes in the airways of cystic fibrosis patients, few cystic fibrosis studies show how P. aeruginosa...
Research Article | Molecular Biology and PhysiologyPseudomonas aeruginosa gshA Mutant Is Defective in Biofilm Formation, Swarming, and Pyocyanin ProductionPseudomonas aeruginosa is a ubiquitous bacterium that can cause severe opportunistic infections, including many hospital-acquired infections. It is also a major cause of infections in patients with cystic fibrosis. P. aeruginosa is intrinsically resistant to a number of drugs and is capable of...
Research Article | Ecological and Evolutionary ScienceHeterogeneous Antimicrobial Susceptibility Characteristics in Pseudomonas aeruginosa Isolates from Cystic Fibrosis PatientsPatients with cystic fibrosis endure “chronic focal infections” with a variety of microorganisms. One microorganism, Pseudomonas aeruginosa, adapts to the host and develops resistance to a wide range of antimicrobials. Interestingly, as the infection progresses, multiple isogenic strains of P. aeruginosa...
Research Article | Host-Microbe BiologyPseudomonas aeruginosa Contact-Dependent Growth Inhibition Plays Dual Role in Host-Pathogen Interactions
Research Article | Applied and Environmental ScienceVisualizing Antimicrobials in Bacterial Biofilms: Three-Dimensional Biochemical Imaging Using TOF-SIMS