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  • Articles
    • Latest Articles
    • COVID-19 Research and News from ASM Journals
    • mSphere of Influence: Commentaries from Early Career Microbiologists
    • Archive
  • Topics
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pregnancy

  • Open Access
    Doesn’t It All Come Down to Function? How To Correlate VAR2CSA Antibodies with Protection
    Letter to the Editor | Host-Microbe Biology
    Doesn’t It All Come Down to Function? How To Correlate VAR2CSA Antibodies with Protection
    Sedami Gnidehou, Stephanie K. Yanow
  • Open Access
    Vaccine Candidate <span class="named-content genus-species" id="named-content-1">Brucella melitensis</span> 16M<em>ΔvjbR</em> Is Safe in a Pregnant Sheep Model and Confers Protection
    Research Article | Therapeutics and Prevention
    Vaccine Candidate Brucella melitensis 16MΔvjbR Is Safe in a Pregnant Sheep Model and Confers Protection

    Brucellosis is one of the most commonly reported zoonotic disease with a worldwide distribution. Of the 12 Brucella species, Brucella melitensis is considered the most virulent and causes reproductive failure (abortions/stillbirths) in small ruminants, which can spread the disease to other animals or to humans. Vaccination of small ruminants is a key measure...

    Martha E. Hensel, Daniel G. Garcia-Gonzalez, Sankar P. Chaki, Airn Hartwig, Paul W. Gordy, Richard Bowen, Thomas A. Ficht, Angela M. Arenas-Gamboa
  • Open Access
    Lack of Evidence for Microbiota in the Placental and Fetal Tissues of Rhesus Macaques
    Research Article | Host-Microbe Biology
    Lack of Evidence for Microbiota in the Placental and Fetal Tissues of Rhesus Macaques

    Microbial invasion of the amniotic cavity (i.e., intra-amniotic infection) has been causally linked to pregnancy complications, especially preterm birth. Therefore, if the placenta and the fetus are typically populated by low-biomass microbial communities, current understanding of the role of microbes in reproduction and pregnancy outcomes will need to be fundamentally reconsidered. Could these communities be of benefit by competitively...

    Kevin R. Theis, Roberto Romero, Andrew D. Winters, Alan H. Jobe, Nardhy Gomez-Lopez
  • Open Access
    mSphere of Influence: Going Native, or the Risk of Overreliance on Recombinant Antigens
    Commentary | Host-Microbe Biology
    mSphere of Influence: Going Native, or the Risk of Overreliance on Recombinant Antigens

    Mary Lopez-Perez works on immunology and pathogenesis of malaria. In this mSphere of Influence article, she reflects on how the paper “Functional antibodies against VAR2CSA in nonpregnant populations from Colombia exposed to Plasmodium falciparum and Plasmodium vivax” by S. Gnidehou, J....

    Mary Lopez-Perez
  • Open Access
    No Consistent Evidence for Microbiota in Murine Placental and Fetal Tissues
    Research Article | Host-Microbe Biology
    No Consistent Evidence for Microbiota in Murine Placental and Fetal Tissues

    The prevailing paradigm in obstetrics has been the sterile womb hypothesis, which posits that fetuses are first colonized by microorganisms during the delivery process. However, some are now suggesting that fetuses are consistently colonized in utero by microorganisms from microbial communities that inhabit the placenta and intra-amniotic environment. Given the established causal role of microbial invasion of the amniotic...

    Kevin R. Theis, Roberto Romero, Jonathan M. Greenberg, Andrew D. Winters, Valeria Garcia-Flores, Kenichiro Motomura, Madison M. Ahmad, Jose Galaz, Marcia Arenas-Hernandez, Nardhy Gomez-Lopez
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