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pneumonia

  • Open Access
    Corrected and Republished from: A Nonfunctional Opsonic Antibody Response Frequently Occurs after Pneumococcal Pneumonia and Is Associated with Invasive Disease
    Research Article | Host-Microbe Biology
    Corrected and Republished from: A Nonfunctional Opsonic Antibody Response Frequently Occurs after Pneumococcal Pneumonia and Is Associated with Invasive Disease

    Numerous reports on the dynamics of antipneumococcal immunity in relation to immunization with pneumococcal vaccines and on the prevalence of naturally acquired immunity in various populations have been published. In contrast, studies on the dynamics of the humoral immune response triggered by pneumococcal infection are scarce.

    Fabian Uddén, Jonas Ahl, Nils Littorin, Kristoffer Strålin, Simon Athlin, Kristian Riesbeck
  • Open Access
    A Nonfunctional Opsonic Antibody Response Frequently Occurs after Pneumococcal Pneumonia and Is Associated with Invasive Disease
    Research Article | Clinical Science and Epidemiology
    A Nonfunctional Opsonic Antibody Response Frequently Occurs after Pneumococcal Pneumonia and Is Associated with Invasive Disease

    Numerous reports on the dynamics of antipneumococcal immunity in relation to immunization with pneumococcal vaccines and on the prevalence of naturally acquired immunity in various populations have been published. In contrast, studies on the dynamics of the humoral immune response triggered by pneumococcal infection are scarce. This study provides valuable information that will contribute to fill this knowledge gap. Our main results...

    Fabian Uddén, Jonas Ahl, Nils Littorin, Kristoffer Strålin, Simon Athlin, Kristian Riesbeck
  • Open Access
    Evaluation of a Validated Luminex-Based Multiplex Immunoassay for Measuring Immunoglobulin G Antibodies in Serum to Pneumococcal Capsular Polysaccharides
    Research Article | Clinical Science and Epidemiology
    Evaluation of a Validated Luminex-Based Multiplex Immunoassay for Measuring Immunoglobulin G Antibodies in Serum to Pneumococcal Capsular Polysaccharides

    The pneumococcal enzyme-linked immunosorbent assay (ELISA) measures IgG antibodies in human serum, and it is an important assay that supports licensure of pneumococcal vaccines. The immune correlate of protection, 0.35 µg/ml of IgG antibodies, was determined by the ELISA method. Pfizer has developed a new Luminex-based assay platform to replace the ELISA. These papers describe the important work of (i) validating the Luminex-based assay...

    Charles Y. Tan, Fred W. Immermann, Shite Sebastian, Michael W. Pride, Danka Pavliakova, Kelly A. Belanger, Wendy Watson, Daniel A. Scott, Mohinder Sidhu, Kathrin U. Jansen, Peter C. Giardina
  • Open Access
    <em>Pseudomonas aeruginosa</em> Protease IV Exacerbates Pneumococcal Pneumonia and Systemic Disease
    Research Article | Host-Microbe Biology
    Pseudomonas aeruginosa Protease IV Exacerbates Pneumococcal Pneumonia and Systemic Disease

    S. pneumoniae remains the leading cause of bacterial pneumonia despite widespread use of pneumococcal vaccines, forcing the necessity for appropriate treatment to control pneumococcal infections. Coinfections involving S. pneumoniae with other bacterial pathogens threaten antibiotic treatment...

    Jessica L. Bradshaw, Armando R. Caballero, Michael A. Bierdeman, Kristen V. Adams, Haley R. Pipkins, Aihua Tang, Richard J. O’Callaghan, Larry S. McDaniel
  • Open Access
    A Serendipitous Mutation Reveals the Severe Virulence Defect of a <span class="named-content genus-species" id="named-content-1">Klebsiella pneumonia</span>e <em>fepB</em> Mutant
    Research Article | Host-Microbe Biology
    A Serendipitous Mutation Reveals the Severe Virulence Defect of a Klebsiella pneumoniae fepB Mutant

    In addition to having a reputation as the causative agent of several types of hospital-acquired infections, Klebsiella pneumoniae has gained widespread attention as a pathogen with a propensity for acquiring antibiotic resistance. It is capable of causing a range of infections, including urinary tract infections, pneumonia, and sepsis. Because of the rapid emergence...

    Michelle Palacios, Christopher A. Broberg, Kimberly A. Walker, Virginia L. Miller
  • Open Access
    Molecular Epidemiology of Colonizing and Infecting Isolates of <span class="named-content genus-species" id="named-content-1">Klebsiella pneumoniae</span>
    Research Article | Clinical Science and Epidemiology
    Molecular Epidemiology of Colonizing and Infecting Isolates of Klebsiella pneumoniae

    K. pneumoniae commonly infects hospitalized patients, and these infections are increasingly resistant to carbapenems, the antibiotics of last resort for life-threatening bacterial infections. To prevent and treat these infections, we must better understand how K. pneumoniae causes disease and...

    Rebekah M. Martin, Jie Cao, Sylvain Brisse, Virginie Passet, Weisheng Wu, Lili Zhao, Preeti N. Malani, Krishna Rao, Michael A. Bachman
  • Open Access
    The Spl Serine Proteases Modulate <span class="named-content genus-species" id="named-content-1">Staphylococcus aureus</span> Protein Production and Virulence in a Rabbit Model of Pneumonia
    Research Article | Host-Microbe Biology
    The Spl Serine Proteases Modulate Staphylococcus aureus Protein Production and Virulence in a Rabbit Model of Pneumonia

    Staphylococcus aureus is a versatile human pathogen that produces an array of virulence factors, including several proteases. Of these, six proteases called the Spls are the least characterized. Previous evidence suggests that the Spls are expressed during human infection; however, their function is unknown. Our study shows that the Spls are required for...

    Alexandra E. Paharik, Wilmara Salgado-Pabon, David K. Meyerholz, Mark J. White, Patrick M. Schlievert, Alexander R. Horswill
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