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    • Archive
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phagocytosis

  • Open Access
    Shielding Effect of <span class="named-content genus-species" id="named-content-1">Escherichia coli</span> O-Antigen Polysaccharide on J5-Induced Cross-Reactive Antibodies
    Research Article | Therapeutics and Prevention
    Shielding Effect of Escherichia coli O-Antigen Polysaccharide on J5-Induced Cross-Reactive Antibodies

    Despite intensive research, mastitis remains an important disease in dairy cattle with a significant impact on animal welfare, use of antibiotics, and, in the end, the economy of dairy farms. Although vaccines available so far have shown limited efficacy against coliform mastitis, vaccination is considered one of the measures that could limit the consequences of mastitis.

    Pascal Rainard, Maryline Repérant-Ferter, Christophe Gitton, Pierre Germon
  • Open Access
    Corrected and Republished from: A Nonfunctional Opsonic Antibody Response Frequently Occurs after Pneumococcal Pneumonia and Is Associated with Invasive Disease
    Research Article | Host-Microbe Biology
    Corrected and Republished from: A Nonfunctional Opsonic Antibody Response Frequently Occurs after Pneumococcal Pneumonia and Is Associated with Invasive Disease

    Numerous reports on the dynamics of antipneumococcal immunity in relation to immunization with pneumococcal vaccines and on the prevalence of naturally acquired immunity in various populations have been published. In contrast, studies on the dynamics of the humoral immune response triggered by pneumococcal infection are scarce.

    Fabian Uddén, Jonas Ahl, Nils Littorin, Kristoffer Strålin, Simon Athlin, Kristian Riesbeck
  • Open Access
    Functional Analysis of the Collagen Binding Proteins of <span class="named-content genus-species" id="named-content-1">Streptococcus parasanguinis</span> FW213
    Research Article | Host-Microbe Biology
    Functional Analysis of the Collagen Binding Proteins of Streptococcus parasanguinis FW213

    Bacteria generally can utilize multiple adhesins to establish themselves in the host. We found that Streptococcus parasanguinis, a dominant oral commensal and an opportunistic pathogen for subacute endocarditis, possesses at least three collagen-binding proteins that enable S. parasanguinis to successfully colonize damaged heart tissues and escape innate...

    Yi-Ywan M. Chen, Pei-Hua Tsai, Zong-Sian Ye, Yu-Wen Huang, Hui-Ru Shieh, Chia-Hua Wu, Yu-Juan Lin, James H. Miller, Jacqueline Abranches, Cheng-Hsun Chiu
  • Open Access
    Extracellular Vesicles from <span class="named-content genus-species" id="named-content-1">Aspergillus flavus</span> Induce M1 Polarization <em>In Vitro</em>
    Research Article | Host-Microbe Biology
    Extracellular Vesicles from Aspergillus flavus Induce M1 Polarization In Vitro

    Immunocompromised patients are susceptible to several fungal infections. The genus Aspergillus can cause increased morbidity and mortality. Developing new therapies is essential to understand the fungal biology mechanisms. Fungal EVs carry important virulence factors, thus playing pivotal roles in fungal pathophysiology. No study to date has reported EV production by...

    Verônica S. Brauer, André M. Pessoni, Tamires A. Bitencourt, Renato G. de Paula, Liliana de Oliveira Rocha, Gustavo H. Goldman, Fausto Almeida
  • Open Access
    Inhibition of Respiration of <span class="named-content genus-species" id="named-content-1">Candida albicans</span> by Small Molecules Increases Phagocytosis Efficacy by Macrophages
    Research Article | Therapeutics and Prevention
    Inhibition of Respiration of Candida albicans by Small Molecules Increases Phagocytosis Efficacy by Macrophages

    The yeast Candida albicans is one of the major fungal human pathogens, for which new therapeutic approaches are required. We aimed at enhancements of the phagocytosis efficacy of macrophages by targeting the cell wall structure of C. albicans, as the coverage of the β-glucan layer by mannans is one...

    Shuna Cui, Minghui Li, Rabeay Y. A. Hassan, Anna Heintz-Buschart, Junsong Wang, Ursula Bilitewski
  • Open Access
    A Nonfunctional Opsonic Antibody Response Frequently Occurs after Pneumococcal Pneumonia and Is Associated with Invasive Disease
    Research Article | Clinical Science and Epidemiology
    A Nonfunctional Opsonic Antibody Response Frequently Occurs after Pneumococcal Pneumonia and Is Associated with Invasive Disease

    Numerous reports on the dynamics of antipneumococcal immunity in relation to immunization with pneumococcal vaccines and on the prevalence of naturally acquired immunity in various populations have been published. In contrast, studies on the dynamics of the humoral immune response triggered by pneumococcal infection are scarce. This study provides valuable information that will contribute to fill this knowledge gap. Our main results...

    Fabian Uddén, Jonas Ahl, Nils Littorin, Kristoffer Strålin, Simon Athlin, Kristian Riesbeck
  • Open Access
    Blocks in Tricarboxylic Acid Cycle of <span class="named-content genus-species" id="named-content-1">Salmonella enterica</span> Cause Global Perturbation of Carbon Storage, Motility, and Host-Pathogen Interaction
    Research Article | Molecular Biology and Physiology
    Blocks in Tricarboxylic Acid Cycle of Salmonella enterica Cause Global Perturbation of Carbon Storage, Motility, and Host-Pathogen Interaction

    We performed perturbation analyses of the tricarboxylic acid cycle of the gastrointestinal pathogen Salmonella enterica serovar Typhimurium. The defect of fumarase activity led to accumulation of fumarate but also resulted in a global alteration of carbon fluxes, leading to increased storage of glycogen. Gross alterations were observed in proteome and metabolome...

    Janina Noster, Nicole Hansmeier, Marcus Persicke, Tzu-Chiao Chao, Rainer Kurre, Jasmin Popp, Viktoria Liss, Tatjana Reuter, Michael Hensel
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