neutralization

  • Open Access
    Association between Antibody Responses to Epstein-Barr Virus Glycoproteins, Neutralization of Infectivity, and the Risk of Nasopharyngeal Carcinoma
    Research Article | Clinical Science and Epidemiology
    Association between Antibody Responses to Epstein-Barr Virus Glycoproteins, Neutralization of Infectivity, and the Risk of Nasopharyngeal Carcinoma

    Epstein-Barr virus (EBV) is a human oncogenic gammaherpesvirus that infects over 90% of humans in the world and is causally associated with a spectrum of epithelial and B-cell malignancies such as nasopharyngeal carcinoma (NPC). A prophylactic vaccine against EBV is called for, but no approved vaccine is available yet.

    Qian-Ying Zhu, Xiang-Wei Kong, Cong Sun, Shang-Hang Xie, Allan Hildesheim, Su-Mei Cao, Mu-Sheng Zeng
  • Open Access
    Norovirus Escape from Broadly Neutralizing Antibodies Is Limited to Allostery-Like Mechanisms
    Research Article | Host-Microbe Biology
    Norovirus Escape from Broadly Neutralizing Antibodies Is Limited to Allostery-Like Mechanisms

    The simplest and most common way for viruses to escape antibody neutralization is by mutating residues that are essential for antibody binding. Escape mutations are strongly selected for by their effect on viral fitness, which is most often related to issues of protein folding, particle assembly, and capsid function. The studies presented here demonstrated that a broadly neutralizing antibody to mouse norovirus binds to an exposed...

    Abimbola O. Kolawole, Hong Q. Smith, Sophia A. Svoboda, Madeline S. Lewis, Michael B. Sherman, Gillian C. Lynch, B. Montgomery Pettitt, Thomas J. Smith, Christiane E. Wobus
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