middle ear
Research Article | Host-Microbe BiologyExamining the Evidence for an Adult Healthy Middle Ear MicrobiomeRecent molecular-based studies have suggested that a diverse middle ear microbiome in adults and children can exist in the absence of disease. These studies have been largely unsupported by culture and feature species that commonly contaminate low-biomass sequencing data. While 16S rRNA gene amplicon sequencing has proven to be a highly informative technique in many clinical contexts, it is susceptible to spurious signal arising from...
Research Article | Host-Microbe BiologyIn Silico Modeling of Biofilm Formation by Nontypeable Haemophilus influenzae In VivoMultiple respiratory illnesses are associated with formation of biofilms within the human airway by NTHI. However, a substantial amount of our understanding of the mechanisms that underlie NTHI biofilm formation is obtained from in vitro studies. Our in silico model that describes biofilm formation by NTHI within the middle ears of Chinchilla lanigera...