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malaria

  • Open Access
    Clustering and Erratic Movement Patterns of Syringe-Injected versus Mosquito-Inoculated Malaria Sporozoites Underlie Decreased Infectivity
    Research Article
    Clustering and Erratic Movement Patterns of Syringe-Injected versus Mosquito-Inoculated Malaria Sporozoites Underlie Decreased Infectivity

    Malaria still causes a major burden on global health and the economy. The efficacy of live, attenuated malaria sporozoites as vaccine candidates critically depends on their ability to migrate to and infect the host liver.

    C. M. de Korne, B. M. F. Winkel, M. N. van Oosterom, S. Chevalley-Maurel, H. M. Houwing, J. C. Sijtsma, S. Azargoshasb, E. Baalbergen, B. M. D. Franke-Fayard, F. W. B. van Leeuwen, M. Roestenberg
  • Open Access
    Additional Feeding Reveals Differences in Immune Recognition and Growth of <em>Plasmodium</em> Parasites in the Mosquito Host
    Research Article
    Additional Feeding Reveals Differences in Immune Recognition and Growth of Plasmodium Parasites in the Mosquito Host

    Mosquitoes must blood feed multiple times to acquire and transmit malaria. However, the impact of an additional mosquito blood meal following malaria parasite infection has not been closely examined.

    Hyeogsun Kwon, Maria L. Simões, Rebekah A. Reynolds, George Dimopoulos, Ryan C. Smith
  • Open Access
    Investigation of Heterochromatin Protein 1 Function in the Malaria Parasite <span class="named-content genus-species" id="named-content-1">Plasmodium falciparum</span> Using a Conditional Domain Deletion and Swapping Approach
    Research Article | Host-Microbe Biology
    Investigation of Heterochromatin Protein 1 Function in the Malaria Parasite Plasmodium falciparum Using a Conditional Domain Deletion and Swapping Approach

    Malaria is caused by unicellular Plasmodium species parasites that repeatedly invade and replicate inside red blood cells. Some blood-stage parasites exit the cell cycle and differentiate into gametocytes that are essential for malaria transmission via the mosquito vector.

    Hai T. N. Bui, Armin Passecker, Nicolas M. B. Brancucci, Till S. Voss
  • Open Access
    The Role of the Histone Methyltransferase PfSET10 in Antigenic Variation by Malaria Parasites: a Cautionary Tale
    Observation | Host-Microbe Biology
    The Role of the Histone Methyltransferase PfSET10 in Antigenic Variation by Malaria Parasites: a Cautionary Tale

    The identification of specific epigenetic regulatory proteins in infectious organisms has become a high-profile research topic and a focus for several drug development initiatives. However, studies that define specific roles for different epigenetic modifiers occasionally report differing results, and we similarly provide evidence regarding the histone methyltransferase PfSET10 that is in stark contrast with previously published results...

    Che J. Ngwa, Mackensie R. Gross, Jean-Pierre Musabyimana, Gabriele Pradel, Kirk W. Deitsch
  • Open Access
    Phosphorylation of the Canonical Histone H2A Marks Foci of Damaged DNA in Malaria Parasites
    Research Article | Molecular Biology and Physiology
    Phosphorylation of the Canonical Histone H2A Marks Foci of Damaged DNA in Malaria Parasites

    Plasmodium falciparum is the deadliest human parasite that causes malaria when it reaches the bloodstream and begins proliferating inside red blood cells, where the parasites are particularly prone to DNA damage. The molecular mechanisms that allow these pathogens to maintain their genome integrity under such conditions are also the driving force for acquiring genome...

    Manish Goyal, Adina Heinberg, Vera Mitesser, Sofiya Kandelis-Shalev, Brajesh Kumar Singh, Ron Dzikowski
  • Open Access
    CRISPR/Cas9-Based Knockout of GNAQ Reveals Differences in Host Cell Signaling Necessary for Egress of Apicomplexan Parasites
    Observation | Host-Microbe Biology
    CRISPR/Cas9-Based Knockout of GNAQ Reveals Differences in Host Cell Signaling Necessary for Egress of Apicomplexan Parasites

    The coordinated release of apicomplexan parasites from infected host cells prior to reinvasion is a critical process for parasite survival and the spread of infection. While Toxoplasma tachyzoites and Plasmodium blood stages induce a fast disruption of their surrounding membranes during their egress from host cells, Plasmodium liver stages keep the host cell membrane intact and leave their host cell in host...

    Paul-Christian Burda, Hugo Bisio, Jean-Baptiste Marq, Dominique Soldati-Favre, Volker T. Heussler
  • Open Access
    Genetic Markers of Adaptation of <span class="named-content genus-species" id="named-content-1">Plasmodium falciparum</span> to Transmission by American Vectors Identified in the Genomes of Parasites from Haiti and South America
    Research Article | Ecological and Evolutionary Science
    Genetic Markers of Adaptation of Plasmodium falciparum to Transmission by American Vectors Identified in the Genomes of Parasites from Haiti and South America

    Historical data suggest that millions of P. falciparum parasite lineages were introduced into the Americas during the trans-Atlantic slave trade, which would suggest a paraphyletic origin of the extant isolates in the Western Hemisphere. Our analyses of whole-genome variants show that the American parasites belong to a well-supported monophyletic clade. We hypothesize...

    Massimiliano S. Tagliamonte, Charles A. Yowell, Maha A. Elbadry, Jacques Boncy, Christian P. Raccurt, Bernard A. Okech, Erica M. Goss, Marco Salemi, John B. Dame
  • Open Access
    Dispensable Role of Mitochondrial Fission Protein 1 (Fis1) in the Erythrocytic Development of <span class="named-content genus-species" id="named-content-1">Plasmodium falciparum</span>
    Observation | Molecular Biology and Physiology
    Dispensable Role of Mitochondrial Fission Protein 1 (Fis1) in the Erythrocytic Development of Plasmodium falciparum

    Malaria is responsible for over 230 million clinical cases and ∼half a million deaths each year. The single mitochondrion of the malaria parasite functions as a metabolic hub throughout the parasite’s developmental cycle (DC) and also as a source of ATP in certain stages. To pass on its essential functions, the parasite’s mitochondrion needs to be properly divided and segregated into all progeny during cell division via a process termed...

    Mulaka Maruthi, Liqin Ling, Jing Zhou, Hangjun Ke
  • Open Access
    Novel Method for the Separation of Male and Female Gametocytes of the Malaria Parasite <em>Plasmodium falciparum</em> That Enables Biological and Drug Discovery
    Research Article | Host-Microbe Biology
    Novel Method for the Separation of Male and Female Gametocytes of the Malaria Parasite Plasmodium falciparum That Enables Biological and Drug Discovery

    The protozoan Plasmodium falciparum causes the most severe form of human malaria. The development of sexual forms (so-called gametocytes) is crucial for disease transmission. However, knowledge of these forms is severely hampered by the paucity of sex-specific markers and the inability to extract single sex gametocytes in high purity. Moreover, the identification of...

    Melanie C. Ridgway, Kwong Sum Shea, Daniela Cihalova, Alexander G. Maier
  • Open Access
    Redesigned TetR-Aptamer System To Control Gene Expression in <span class="named-content genus-species" id="named-content-1">Plasmodium falciparum</span>
    Research Article | Molecular Biology and Physiology
    Redesigned TetR-Aptamer System To Control Gene Expression in Plasmodium falciparum

    Malaria elimination efforts have been repeatedly hindered by the evolution and spread of multidrug-resistant strains of Plasmodium falciparum. The absence of a commercially available vaccine emphasizes the need for a better understanding of Plasmodium biology in order to further translational research. This has been partly facilitated by targeted gene...

    Krithika Rajaram, Hans B. Liu, Sean T. Prigge

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