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Klebsiella

  • Open Access
    IMP-68, a Novel IMP-Type Metallo-β-Lactamase in Imipenem-Susceptible <span class="named-content genus-species" id="named-content-1">Klebsiella pneumoniae</span>
    Observation | Clinical Science and Epidemiology
    IMP-68, a Novel IMP-Type Metallo-β-Lactamase in Imipenem-Susceptible Klebsiella pneumoniae

    IMP-type metallo-β-lactamases comprise one group of the “Big 5” carbapenemases. Here, a novel blaIMP-68 gene encoding IMP-68 (harboring a Ser262Gly point mutant of IMP-11) was discovered from meropenem-resistant but imipenem-susceptible Klebsiella pneumoniae TA6363. The Ser262Gly substitution was previously identified as important for substrate...

    Hiroaki Kubota, Yasunori Suzuki, Rumi Okuno, Yumi Uchitani, Tsukasa Ariyoshi, Nobuyuki Takemura, Fuminori Mihara, Kazuhisa Mezaki, Norio Ohmagari, Mari Matsui, Satowa Suzuki, Tsuyoshi Sekizuka, Makoto Kuroda, Keiko Yokoyama, Kenji Sadamasu
  • Open Access
    Emergence of New Delhi Metallo-β-Lactamase (NDM-5) in <em>Klebsiella quasipneumoniae</em> from Neonates in a Nigerian Hospital
    Research Article | Clinical Science and Epidemiology
    Emergence of New Delhi Metallo-β-Lactamase (NDM-5) in Klebsiella quasipneumoniae from Neonates in a Nigerian Hospital

    Carbapenem-resistant Klebsiella pneumoniae is of global health importance, yet there is a paucity of genome-based studies in Africa. Here we report fatal blood-borne NDM-5-producing K. quasipneumoniae subsp. similipneumoniae infections from Nigeria, Africa. New Delhi metallo-β-lactamase (...

    Lauren M. Brinkac, Richard White, Roshan D’Souza, Kevin Nguyen, Stephen K. Obaro, Derrick E. Fouts
  • Open Access
    A New Take on an Old Remedy: Generating Antibodies against Multidrug-Resistant Gram-Negative Bacteria in a Postantibiotic World
    Perspective | Therapeutics and Prevention
    A New Take on an Old Remedy: Generating Antibodies against Multidrug-Resistant Gram-Negative Bacteria in a Postantibiotic World

    With the problem of multidrug-resistant Gram-negative pathogens becoming increasingly dire, new strategies are needed to protect and treat infected patients. Though abandoned in the past, monoclonal antibody therapy against Gram-negative bacteria remains a potential solution and has potential advantages over the broad-spectrum antibiotics they were once replaced by.

    Michael P. Motley, Bettina C. Fries
  • Open Access
    A Serendipitous Mutation Reveals the Severe Virulence Defect of a <span class="named-content genus-species" id="named-content-1">Klebsiella pneumonia</span>e <em>fepB</em> Mutant
    Research Article | Host-Microbe Biology
    A Serendipitous Mutation Reveals the Severe Virulence Defect of a Klebsiella pneumoniae fepB Mutant

    In addition to having a reputation as the causative agent of several types of hospital-acquired infections, Klebsiella pneumoniae has gained widespread attention as a pathogen with a propensity for acquiring antibiotic resistance. It is capable of causing a range of infections, including urinary tract infections, pneumonia, and sepsis. Because of the rapid emergence...

    Michelle Palacios, Christopher A. Broberg, Kimberly A. Walker, Virginia L. Miller
  • Open Access
    Molecular Epidemiology of Colonizing and Infecting Isolates of <span class="named-content genus-species" id="named-content-1">Klebsiella pneumoniae</span>
    Research Article | Clinical Science and Epidemiology
    Molecular Epidemiology of Colonizing and Infecting Isolates of Klebsiella pneumoniae

    K. pneumoniae commonly infects hospitalized patients, and these infections are increasingly resistant to carbapenems, the antibiotics of last resort for life-threatening bacterial infections. To prevent and treat these infections, we must better understand how K. pneumoniae causes disease and...

    Rebekah M. Martin, Jie Cao, Sylvain Brisse, Virginie Passet, Weisheng Wu, Lili Zhao, Preeti N. Malani, Krishna Rao, Michael A. Bachman
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