host-pathogen interactions
Research ArticleAdditional Feeding Reveals Differences in Immune Recognition and Growth of Plasmodium Parasites in the Mosquito HostMosquitoes must blood feed multiple times to acquire and transmit malaria. However, the impact of an additional mosquito blood meal following malaria parasite infection has not been closely examined.
CommentarymSphere of Influence: Viruses—Pathogens or Expert Cell Biologists?Chelsey C. Spriggs works in the field of DNA viral entry with a specific interest in virus-host interactions.
Research ArticleSerum Antibody Responses against Carbapenem-Resistant Klebsiella pneumoniae in Infected PatientsCarbapenem-resistant Klebsiella pneumoniae is a rapidly emerging public health threat that can cause fatal infections in up to 50% of affected patients. Due to its resistance to nearly all antimicrobials, development of alternate therapies like antibodies and vaccines is urgently needed.
Editor's Pick Research Article | Host-Microbe BiologyOuter Membrane Structural Defects in Salmonella enterica Serovar Typhimurium Affect Neutrophil Chemokinesis but Not ChemotaxisNeutrophils are the first responders to invading pathogens; thus, understanding their migratory response to live pathogens is crucial. We developed a microfluidic assay that separates bacteria from phagocytic neutrophils while maintaining chemical communication between the two populations.
Research Article | Host-Microbe BiologyTranscription Repressor Protein ZBTB25 Associates with HDAC1-Sin3a Complex in Mycobacterium tuberculosis-Infected Macrophages, and Its Inhibition Clears Pathogen by AutophagyFollowing infection with M. tuberculosis, levels of HDAC1 go up in macrophages, and it is recruited to the promoter of IL-12B where it hypoacetylates histone H3, leading to the downregulation of the gene. Here, we show that host transcriptional repressor protein ZBTB25 and transcriptional corepressor Sin3a associate with HDAC1 in the silencing complex.
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Observation | Clinical Science and EpidemiologyFunctional Characterization of Circulating Mumps Viruses with Stop Codon Mutations in the Small Hydrophobic ProteinMumps virus (MuV) outbreaks occur in the United States despite high coverage with measles, mumps, rubella (MMR) vaccine. Routine genotyping of laboratory-confirmed mumps cases has been practiced in the United States since 2006 to enhance mumps surveillance. This study reports the detection of unusual mutations in the small hydrophobic (SH) protein of contemporary laboratory-confirmed mumps cases and is the first to describe the impact...
Research Article | Host-Microbe BiologyTranscriptional Profiling Suggests T Cells Cluster around Neurons Injected with Toxoplasma gondii ProteinsLike other persistent intracellular pathogens, Toxoplasma gondii, a protozoan parasite, has evolved to evade the immune system and establish a chronic infection in specific cells and organs, including neurons in the CNS. Understanding T. gondii’s persistence in neurons holds the potential to identify novel, curative drug targets. The work presented here...
Research Article | Host-Microbe BiologyComparative Evaluations of the Pathogenesis of Candida auris Phenotypes and Candida albicans Using Clinically Relevant Murine Models of InfectionsThe newly emerged Candida species C. auris has been associated with an exponential rise in invasive disease in health care facilities worldwide with a mortality rate approaching 60%. C. auris exhibits a high level of transmissibility, multidrug resistance, and persistence in hospital...
Research Article | Host-Microbe BiologyCandida auris Phenotypic Heterogeneity Determines Pathogenicity In VitroCandida auris has recently emerged as an important cause of concern within health care environments due to its ability to persist and tolerate commonly used antiseptics and disinfectants, particularly when attached to a surface (biofilms). This yeast is able to colonize and subsequently infect patients, particularly those that are critically ill or immunosuppressed,...
Research Article | Host-Microbe BiologyHost-Induced Genome Instability Rapidly Generates Phenotypic Variation across Candida albicans Strains and Ploidy StatesCandida albicans is an opportunistic fungal pathogen of humans. The ability to generate genetic variation is essential for adaptation and is a strategy that C. albicans and other fungal pathogens use to change their genome size. Stressful environments, including the host, induce...