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    • mSphere of Influence: Commentaries from Early Career Microbiologists
    • Archive
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host-microbe interactions

  • Open Access
    Oxalate-Degrading <span class="named-content genus-species" id="named-content-1">Bacillus subtilis</span> Mitigates Urolithiasis in a <span class="named-content genus-species" id="named-content-2">Drosophila melanogaster</span> Model
    Research Article | Therapeutics and Prevention
    Oxalate-Degrading Bacillus subtilis Mitigates Urolithiasis in a Drosophila melanogaster Model

    Kidney stone disease is a morbid condition that is increasing in prevalence, with few nonsurgical treatment options. The majority of stones are composed of calcium oxalate. Unlike humans, some microbes can break down oxalate, suggesting that microbial therapeutics may provide a novel treatment for kidney stone patients. This study demonstrated that Bacillus subtilis...

    Kait F. Al, Brendan A. Daisley, Ryan M. Chanyi, Jennifer Bjazevic, Hassan Razvi, Gregor Reid, Jeremy P. Burton
  • Open Access
    Reproductive System Symbiotic Bacteria Are Conserved between Two Distinct Populations of <em>Euprymna scolopes</em> from Oahu, Hawaii
    Research Article | Host-Microbe Biology
    Reproductive System Symbiotic Bacteria Are Conserved between Two Distinct Populations of Euprymna scolopes from Oahu, Hawaii

    In this study, we examined the reproductive ANG symbiosis found in two genetically isolated populations of the Hawaiian bobtail squid, Euprymna scolopes. The stability of the community reported here provides support for the hypothesis that this symbiosis is under strong selective pressure, while the observed differences suggest that some level of local adaptation may have occurred. These two host populations are frequently used...

    Allison H. Kerwin, Spencer V. Nyholm
  • Open Access
    Studying the Symbiotic Bacterium <span class="named-content genus-species" id="named-content-1">Xenorhabdus nematophila</span> in Individual, Living <em>Steinernema carpocapsae</em> Nematodes Using Microfluidic Systems
    Research Article | Host-Microbe Biology
    Studying the Symbiotic Bacterium Xenorhabdus nematophila in Individual, Living Steinernema carpocapsae Nematodes Using Microfluidic Systems

    This paper describes an experimental system for directly investigating population dynamics of a symbiotic bacterium, Xenorhabdus nematophila, in its host—the infective stage of the entomopathogenic nematode Steinernema carpocapsae. Tracking individual and groups of bacteria in individual host nematodes over days and weeks yielded insight into dynamic growth...

    Matthew D. Stilwell, Mengyi Cao, Heidi Goodrich-Blair, Douglas B. Weibel
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