host-cell interactions

  • Open Access
    <em>N</em>-Acetylglucosamine Metabolism Promotes Survival of <span class="named-content genus-species" id="named-content-1">Candida albicans</span> in the Phagosome
    Research Article | Host-Microbe Biology
    N-Acetylglucosamine Metabolism Promotes Survival of Candida albicans in the Phagosome

    Candida albicans is the most important medically relevant fungal pathogen, with disseminated candidiasis being the fourth most common hospital-associated bloodstream infection. Macrophages and neutrophils are innate immune cells that play a key role in host defense by phagocytosing and destroying C....

    Elisa M. Vesely, Robert B. Williams, James B. Konopka, Michael C. Lorenz
  • Open Access
    Drug Repurposing Screening Identifies Novel Compounds That Effectively Inhibit <span class="named-content genus-species" id="named-content-1">Toxoplasma gondii</span> Growth
    Research Article | Therapeutics and Prevention
    Drug Repurposing Screening Identifies Novel Compounds That Effectively Inhibit Toxoplasma gondii Growth

    There is an urgent need to develop new therapies to treat microbial infections, and the repurposing of well-characterized compounds is emerging as one approach to achieving this goal. Using the protozoan parasite Toxoplasma gondii, we screened a library of 1,120 compounds and identified several compounds with significant antiparasitic activities. Among these were...

    Ashley J. Dittmar, Allison A. Drozda, Ira J. Blader
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