HLH-type transcription factor

  • Open Access
    Pho4 Is Essential for Dissemination of <span class="named-content genus-species" id="named-content-1">Cryptococcus neoformans</span> to the Host Brain by Promoting Phosphate Uptake and Growth at Alkaline pH
    Editor's Pick Research Article | Host-Microbe Biology
    Pho4 Is Essential for Dissemination of Cryptococcus neoformans to the Host Brain by Promoting Phosphate Uptake and Growth at Alkaline pH

    Cryptococcal meningitis is fatal without treatment and responsible for more than 500,000 deaths annually. To be a successful pathogen, C. neoformans must obtain an adequate supply of essential nutrients, including phosphate, from various host niches. Phosphate acquisition in fungi is regulated by the PHO signaling cascade, which is activated when intracellular...

    Sophie Lev, Keren Kaufman-Francis, Desmarini Desmarini, Pierre G. Juillard, Cecilia Li, Sebastian A. Stifter, Carl G. Feng, Tania C. Sorrell, Georges E. R. Grau, Yong-Sun Bahn, Julianne T. Djordjevic
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