herpesviruses
Research Article | Host-Microbe BiologyHerpes Simplex Virus Glycoprotein C Regulates Low-pH EntryHerpesviruses are ubiquitous pathogens that cause lifelong latent infections and that are characterized by multiple entry pathways. We propose that herpes simplex virus (HSV) gC plays a selective role in modulating HSV entry, such as entry into epithelial cells, by a low-pH pathway. gC facilitates a conformational change of the main fusogen gB, a class III fusion protein. We propose a model whereby gC functions with gB, gD, and gH/gL to...
Letter to the Editor | Clinical Science and EpidemiologyAutism Link to Herpes Simplex Virus 2 Antibody in Pregnancy Likely To Be Spurious
Resource Report | Ecological and Evolutionary ScienceDNA from Dust: Comparative Genomics of Large DNA Viruses in Field Surveillance SamplesDespite both clinical and laboratory data that show increased virulence in field isolates of MDV-1 over the last half century, we do not yet understand the genetic basis of its pathogenicity. Our knowledge of genome-wide variation between strains of this virus comes exclusively from isolates that have been cultured in the laboratory. MDV-1 isolates tend to lose virulence during repeated cycles of replication in the laboratory, raising...
Editor's Pick Research Article | Molecular Biology and PhysiologyA Gammaherpesvirus Noncoding RNA Is Essential for Hematogenous Dissemination and Establishment of Peripheral LatencyNoncoding RNAs (ncRNAs) represent an intriguing and diverse class of molecules that are now recognized for their participation in a wide array of cellular processes. Viruses from multiple families have evolved to encode their own such regulatory RNAs; however, the specific in vivo functions of these ncRNAs are largely unknown. Epstein-Barr virus (EBV) and Kaposi’s sarcoma-associated herpesvirus (KSHV) are ubiquitous human...
Editor's Pick Research Article | Host-Microbe BiologyIsolation and Characterization of a Novel Gammaherpesvirus from a Microbat Cell LineBats are of significant interest as reservoirs for zoonotic viral pathogens; however, tools to dissect bat-virus interactions are limited in availability. This study serendipitously identified, in an established bat cell line, a fully replication-competent gammaherpesvirus; determined the complete genome sequence of the virus; and generated a viral transcript map. This virus can replicate in select human and nonhuman primate cell lines...