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hemagglutinin

  • Open Access
    Protein Microarray Analysis of the Specificity and Cross-Reactivity of Influenza Virus Hemagglutinin-Specific Antibodies
    Research Article | Clinical Science and Epidemiology
    Protein Microarray Analysis of the Specificity and Cross-Reactivity of Influenza Virus Hemagglutinin-Specific Antibodies

    Seasonal influenza is a serious public health problem because the viral infection spreads easily from person to person and because of antigenic drift in neutralizing epitopes. Influenza vaccination is the most effective way to prevent the disease, although challenging because of the constant evolution of influenza virus subtypes. Our high-throughput protein microarrays allow for interrogation of subunit-specific IgG and IgA responses to...

    Rie Nakajima, Medalyn Supnet, Algis Jasinskas, Aarti Jain, Omid Taghavian, Joshua Obiero, Donald K. Milton, Wilbur H. Chen, Michael Grantham, Richard Webby, Florian Krammer, Darrick Carter, Philip L. Felgner, D. Huw Davies
  • Open Access
    Stability of the Influenza Virus Hemagglutinin Protein Correlates with Evolutionary Dynamics
    Research Article | Ecological and Evolutionary Science
    Stability of the Influenza Virus Hemagglutinin Protein Correlates with Evolutionary Dynamics

    One of the constraints on fast-evolving viruses, such as influenza virus, is protein stability, or how strongly the folded protein holds together. Despite the importance of this protein property, there has been limited investigation of the impact of the stability of the influenza virus hemagglutinin protein—the primary antibody target of the immune system—on its evolution. Using a combination of computational estimates of stability and...

    Eili Y. Klein, Deena Blumenkrantz, Adrian Serohijos, Eugene Shakhnovich, Jeong-Mo Choi, João V. Rodrigues, Brendan D. Smith, Andrew P. Lane, Andrew Feldman, Andrew Pekosz
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