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gene expression

  • Open Access
    Transcription Profiles Associated with Inducible Adhesion in <span class="named-content genus-species" id="named-content-1">Candida parapsilosis</span>
    Research Article | Host-Microbe Biology
    Transcription Profiles Associated with Inducible Adhesion in Candida parapsilosis

    Invasive Candida infections are frequent complications of the immunocompromised and are associated with substantive morbidity and mortality. Although C. albicans is the best-studied species, emerging infections by non-albicans Candida species have led to increased efforts to understand aspects of their pathogenesis that are unique from...

    Joseph M. Bliss, George A. Tollefson, Abigail Cuevas, Sarah J. Longley, Matthew N. Neale, Alper Uzun, Sunil K. Shaw
  • Open Access
    Laboratory Evolution Experiments Help Identify a Predominant Region of Constitutive Stable DNA Replication Initiation
    Research Article | Molecular Biology and Physiology
    Laboratory Evolution Experiments Help Identify a Predominant Region of Constitutive Stable DNA Replication Initiation

    The bacterium E. coli can replicate its DNA even in the absence of the molecules that are required for canonical replication initiation. This often requires the formation of RNA-DNA hybrid structures and is referred to as constitutive stable DNA replication (cSDR). Where on the chromosome does cSDR initiate? We answer this question using laboratory evolution...

    Reshma T. Veetil, Nitish Malhotra, Akshara Dubey, Aswin Sai Narain Seshasayee
  • Open Access
    Functional Characterization of <span class="named-content genus-species" id="named-content-1">Entamoeba histolytica</span> Argonaute Proteins Reveals a Repetitive DR-Rich Motif Region That Controls Nuclear Localization
    Research Article | Host-Microbe Biology
    Functional Characterization of Entamoeba histolytica Argonaute Proteins Reveals a Repetitive DR-Rich Motif Region That Controls Nuclear Localization

    The protozoan parasite Entamoeba histolytica, which causes amebiasis and affects over 50 million people worldwide, contains an important RNAi pathway for gene silencing. Gene silencing via the RNAi pathway is mediated by the Argonaute (Ago) proteins. However, we lack knowledge on Ago function(s) in this nonmodel system. In this paper, we discovered that three...

    Hanbang Zhang, Vy Tran, Dipak Manna, Gretchen Ehrenkaufer, Upinder Singh
  • Open Access
    Filamentation Is Associated with Reduced Pathogenicity of Multiple Non-<em>albicans Candida</em> Species
    Editor's Pick Observation | Host-Microbe Biology
    Filamentation Is Associated with Reduced Pathogenicity of Multiple Non-albicans Candida Species

    Many immunocompromised individuals, including HIV/AIDS and cancer patients, are susceptible to candidiasis. About half of all cases are caused by the major fungal pathogen Candida albicans, whereas the remainder are due to less pathogenic non-albicans Candida species (NACS). Generation of filamentous cells represents a major virulence property of...

    Mohua Banerjee, Anna L. Lazzell, Jesus A. Romo, Jose L. Lopez-Ribot, David Kadosh
  • Open Access
    Activation of the Extracytoplasmic Function σ Factor σ<sup>P</sup> by β-Lactams in <span class="named-content genus-species" id="named-content-1">Bacillus thuringiensis</span> Requires the Site-2 Protease RasP
    Research Article | Molecular Biology and Physiology
    Activation of the Extracytoplasmic Function σ Factor σP by β-Lactams in Bacillus thuringiensis Requires the Site-2 Protease RasP

    The discovery of antibiotics to treat bacterial infections has had a dramatic and positive impact on human health. However, shortly after the introduction of a new antibiotic, bacteria often develop resistance. The bacterial cell envelope is essential for cell viability and is the target of many of the most commonly used antibiotics, including β-lactam antibiotics. Resistance to β-lactams is often dependent upon β-lactamases. In...

    Theresa D. Ho, Kelsie M. Nauta, Ute Müh, Craig D. Ellermeier
  • Open Access
    Titrating Gene Function in the Human Fungal Pathogen <span class="named-content genus-species" id="named-content-1">Candida albicans</span> through Poly-Adenosine Tract Insertion
    Research Article | Molecular Biology and Physiology
    Titrating Gene Function in the Human Fungal Pathogen Candida albicans through Poly-Adenosine Tract Insertion

    Investigating a protein’s functional importance at the whole-organism level usually involves altering its expression level or its specific activity and observing the consequences with respect to physiology or phenotype. Several approaches designed to partially or completely abolish the function of a gene, including its deletion from the genome and the use of systems that facilitate conditional expression, have been widely applied....

    Helene Tournu, Arielle Butts, Glen E. Palmer
  • Open Access
    Functionally Related Genes Cluster into Genomic Regions That Coordinate Transcription at a Distance in <span class="named-content genus-species" id="named-content-1">Saccharomyces cerevisiae</span>
    Research Article | Molecular Biology and Physiology
    Functionally Related Genes Cluster into Genomic Regions That Coordinate Transcription at a Distance in Saccharomyces cerevisiae

    The two-dimensional, physical positioning of genes along a chromosome can impact proper transcriptional regulation throughout a genomic region. The transcription of neighboring genes is correlated in a genome-wide manner, which is a characteristic of eukaryotes. Many coregulated gene families can be found clustered with another member of the same set—which can result in adjacent gene coregulation of the pair. Due to the myriad gene...

    Alanna Cera, Maria K. Holganza, Ahmad Abu Hardan, Irvin Gamarra, Reem S. Eldabagh, Megan Deschaine, Sarah Elkamhawy, Exequiel M. Sisso, Jonathan J. Foley, James T. Arnone
  • Open Access
    Transcriptome Assembly and Profiling of <em>Candida auris</em> Reveals Novel Insights into Biofilm-Mediated Resistance
    Editor's Pick Research Article | Therapeutics and Prevention
    Transcriptome Assembly and Profiling of Candida auris Reveals Novel Insights into Biofilm-Mediated Resistance

    Fungal infections represent an important cause of human morbidity and mortality, particularly if the fungi adhere to and grow on both biological and inanimate surfaces as communities of cells (biofilms). Recently, a previously unrecognized yeast, Candida auris, has emerged globally that has led to widespread concern due to the difficulty in treating it with existing...

    Ryan Kean, Christopher Delaney, Leighann Sherry, Andrew Borman, Elizabeth M. Johnson, Malcolm D. Richardson, Riina Rautemaa-Richardson, Craig Williams, Gordon Ramage
  • Open Access
    Systematic Identification, Characterization, and Conservation of Adjacent-Gene Coregulation in the Budding Yeast <span class="named-content genus-species" id="named-content-1">Saccharomyces cerevisiae</span>
    Research Article | Molecular Biology and Physiology
    Systematic Identification, Characterization, and Conservation of Adjacent-Gene Coregulation in the Budding Yeast Saccharomyces cerevisiae

    The spatial positioning of genes throughout the genome arrangement can alter their expression in many eukaryotic organisms. Often this results in a genomic context-specific effect on transcription. One example of this is through the clustering of functionally related genes, which results in adjacent-gene coregulation in the budding yeast Saccharomyces cerevisiae. In...

    Reem S. Eldabagh, Nelson G. Mejia, Rachel L. Barrett, Christopher R. Monzo, Matthew K. So, Jonathan J. Foley, James T. Arnone
  • Open Access
    Single-Cell Analysis Reveals Distinct Gene Expression and Heterogeneity in Male and Female <span class="named-content genus-species" id="named-content-1">Plasmodium falciparum</span> Gametocytes
    Research Article | Molecular Biology and Physiology
    Single-Cell Analysis Reveals Distinct Gene Expression and Heterogeneity in Male and Female Plasmodium falciparum Gametocytes

    Most human deaths that result from malaria are caused by the eukaryotic parasite Plasmodium falciparum. The only form of this parasite that is transmitted to the mosquito is the sexual form, called the gametocyte. The production of mature gametocytes can take up to 2 weeks and results in phenotypically distinct males and females, although what causes this gender-...

    Katelyn A. Walzer, Danielle M. Kubicki, Xiaohu Tang, Jen-Tsan Ashley Chi

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