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    • Latest Articles
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    • mSphere of Influence: Commentaries from Early Career Microbiologists
    • Archive
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fungal pathogenesis

  • Open Access
    Aggregate Filamentous Growth Responses in Yeast
    Research Article | Molecular Biology and Physiology
    Aggregate Filamentous Growth Responses in Yeast

    Filamentous growth is a fungal morphogenetic response that is critical for virulence in some fungal species. Many aspects of filamentous growth remain poorly understood. We have identified an aspect of filamentous growth in the budding yeast Saccharomyces cerevisiae and the human pathogen Candida albicans...

    Jacky Chow, Heather M. Dionne, Aditi Prabhakar, Amit Mehrotra, Jenn Somboonthum, Beatriz Gonzalez, Mira Edgerton, Paul J. Cullen
  • Open Access
    Characterizing the Pathogenic, Genomic, and Chemical Traits of <em>Aspergillus fischeri</em>, a Close Relative of the Major Human Fungal Pathogen <em>Aspergillus fumigatus</em>
    Editor's Pick Research Article | Ecological and Evolutionary Science
    Characterizing the Pathogenic, Genomic, and Chemical Traits of Aspergillus fischeri, a Close Relative of the Major Human Fungal Pathogen Aspergillus fumigatus

    Aspergillus fumigatus is the primary cause of aspergillosis, a devastating ensemble of diseases associated with severe morbidity and mortality worldwide. A. fischeri is a close relative of A. fumigatus but is not generally...

    Matthew E. Mead, Sonja L. Knowles, Huzefa A. Raja, Sarah R. Beattie, Caitlin H. Kowalski, Jacob L. Steenwyk, Lilian P. Silva, Jessica Chiaratto, Laure N. A. Ries, Gustavo H. Goldman, Robert A. Cramer, Nicholas H. Oberlies, Antonis Rokas
  • Open Access
    Pho4 Is Essential for Dissemination of <span class="named-content genus-species" id="named-content-1">Cryptococcus neoformans</span> to the Host Brain by Promoting Phosphate Uptake and Growth at Alkaline pH
    Editor's Pick Research Article | Host-Microbe Biology
    Pho4 Is Essential for Dissemination of Cryptococcus neoformans to the Host Brain by Promoting Phosphate Uptake and Growth at Alkaline pH

    Cryptococcal meningitis is fatal without treatment and responsible for more than 500,000 deaths annually. To be a successful pathogen, C. neoformans must obtain an adequate supply of essential nutrients, including phosphate, from various host niches. Phosphate acquisition in fungi is regulated by the PHO signaling cascade, which is activated when intracellular...

    Sophie Lev, Keren Kaufman-Francis, Desmarini Desmarini, Pierre G. Juillard, Cecilia Li, Sebastian A. Stifter, Carl G. Feng, Tania C. Sorrell, Georges E. R. Grau, Yong-Sun Bahn, Julianne T. Djordjevic
  • Open Access
    Potential Roles of Fungal Extracellular Vesicles during Infection
    Minireview | Host-Microbe Biology
    Potential Roles of Fungal Extracellular Vesicles during Infection

    Extracellular vesicles (EVs) are produced by virtually all cell types. Within the past few years, work in this field has revealed more information about fungal EVs. Fungal EVs have been shown to carry proteins, lipids, pigments, polysaccharides, and RNA; these components are known virulence factors, a fact which supports the hypothesis that fungal EVs concentrate pathogenic determinants.

    Luna S. Joffe, Leonardo Nimrichter, Marcio L. Rodrigues, Maurizio Del Poeta
  • Open Access
    RbdB, a Rhomboid Protease Critical for SREBP Activation and Virulence in <em>Aspergillus fumigatus</em>
    Research Article | Host-Microbe Biology
    RbdB, a Rhomboid Protease Critical for SREBP Activation and Virulence in Aspergillus fumigatus

    Aspergillus fumigatus causes life-threatening infections, and treatment options remain limited. Thus, there is an urgent need to find new therapeutic targets to treat this deadly disease. Previously, we have shown that SREBP transcription factors and their regulatory components are critical for the pathobiology of A. fumigatus. Here we identify a role for RbdB, a rhomboid protease, as an essential component of SREBP...

    Sourabh Dhingra, Caitlin H. Kowalski, Arsa Thammahong, Sarah R. Beattie, Katherine M. Bultman, Robert A. Cramer
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