fibrinogen

  • Open Access
    Human Immunoglobulin G Cannot Inhibit Fibrinogen Binding by the Genetically Diverse A Domain of <span class="named-content genus-species" id="named-content-1">Staphylococcus aureus</span> Fibronectin-Binding Protein A
    Research Article | Host-Microbe Biology
    Human Immunoglobulin G Cannot Inhibit Fibrinogen Binding by the Genetically Diverse A Domain of Staphylococcus aureus Fibronectin-Binding Protein A

    Despite the many in vitro and murine in vivo studies involving FnBPA, the actual presence of this virulence factor during human infection is less well established. Furthermore, it is currently unknown to what extent sequence variation in such a virulence factor affects the human antibody response and the ability of antibodies to interfere with FnBPA function. This study sheds new light on these issues. First, the...

    P. Martijn den Reijer, Mehri Tavakol, Nicole Lemmens-den Toom, Dikra Allouch, Sheila Thomas, Vannakambadi K. Ganesh, Ya-Ping Ko, Henri A. Verbrugh, Willem J. B. van Wamel
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