Enterococcus

  • Open Access
    (p)ppGpp and CodY Promote <span class="named-content genus-species" id="named-content-1">Enterococcus faecalis</span> Virulence in a Murine Model of Catheter-Associated Urinary Tract Infection
    Research Article | Molecular Biology and Physiology
    (p)ppGpp and CodY Promote Enterococcus faecalis Virulence in a Murine Model of Catheter-Associated Urinary Tract Infection

    Catheter-associated urinary tract infections (CAUTIs) are one of the most frequent types of infection found in the hospital setting that can develop into serious and potentially fatal bloodstream infections. One of the infectious agents that frequently causes complicated CAUTI is the bacterium Enterococcus faecalis, a leading cause of hospital-acquired infections that...

    C. Colomer-Winter, A. L. Flores-Mireles, S. Kundra, S. J. Hultgren, J. A. Lemos
  • Open Access
    Genomewide Profiling of the <span class="named-content genus-species" id="named-content-1">Enterococcus faecalis</span> Transcriptional Response to Teixobactin Reveals CroRS as an Essential Regulator of Antimicrobial Tolerance
    Research Article | Molecular Biology and Physiology
    Genomewide Profiling of the Enterococcus faecalis Transcriptional Response to Teixobactin Reveals CroRS as an Essential Regulator of Antimicrobial Tolerance

    Teixobactin is a new antimicrobial with no known mechanisms of resistance. Understanding how resistance could develop will be crucial to the success and longevity of teixobactin as a new potent antimicrobial. Antimicrobial tolerance has been shown to facilitate the development of resistance, and we show that E. faecalis is intrinsically tolerant to teixobactin at high...

    Rachel L. Darnell, Melanie K. Knottenbelt, Francesca O. Todd Rose, Ian R. Monk, Timothy P. Stinear, Gregory M. Cook
  • Open Access
    A Novel Biomimetic Nanosponge Protects the Retina from the <span class="named-content genus-species" id="named-content-1">Enterococcus faecalis</span> Cytolysin
    Research Article | Therapeutics and Prevention
    A Novel Biomimetic Nanosponge Protects the Retina from the Enterococcus faecalis Cytolysin

    Endophthalmitis is a serious, potentially blinding infection that can result in vision loss, leaving a patient with only the ability to count fingers, or it may require enucleation of the globe. The incidence of postoperative endophthalmitis has markedly increased over the past 2 decades, paralleling the rise in ocular surgeries and intravitreal therapies. E. faecalis...

    Austin L. LaGrow, Phillip S. Coburn, Frederick C. Miller, Craig Land, Salai Madhumathi Parkunan, Brian T. Luk, Weiwei Gao, Liangfang Zhang, Michelle C. Callegan
  • Open Access
    CRISPR-Cas and Restriction-Modification Act Additively against Conjugative Antibiotic Resistance Plasmid Transfer in <span class="named-content genus-species" id="named-content-1">Enterococcus faecalis</span>
    Editor's Pick Research Article | Molecular Biology and Physiology
    CRISPR-Cas and Restriction-Modification Act Additively against Conjugative Antibiotic Resistance Plasmid Transfer in Enterococcus faecalis

    Enterococcus faecalis is a bacterium that normally inhabits the gastrointestinal tracts of humans and other animals. Although these bacteria are members of our native gut flora, they can cause life-threatening infections in hospitalized patients. Antibiotic resistance genes appear to be readily shared among high-risk...

    Valerie J. Price, Wenwen Huo, Ardalan Sharifi, Kelli L. Palmer
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