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dendritic cells

  • Open Access
    An Important Role for CD4<sup>+</sup> T Cells in Adaptive Immunity to <span class="named-content genus-species" id="named-content-1">Toxoplasma gondii</span> in Mice Lacking the Transcription Factor Batf3
    Research Article | Host-Microbe Biology
    An Important Role for CD4+ T Cells in Adaptive Immunity to Toxoplasma gondii in Mice Lacking the Transcription Factor Batf3

    Toxoplasma gondii is a widespread parasite of animals that causes zoonotic infections in humans. Although healthy individuals generally control the infection with only moderate symptoms, it causes serious illness in newborns and those with compromised immune systems such as HIV-infected AIDS patients. Because rodents are natural hosts for...

    Roxane Tussiwand, Michael S. Behnke, Nicole M. Kretzer, Gary E. Grajales-Reyes, Theresa L. Murphy, Robert D. Schreiber, Kenneth M. Murphy, L. David Sibley
  • Open Access
    Vitamin A Metabolism by Dendritic Cells Triggers an Antimicrobial Response against <span class="named-content genus-species" id="named-content-1">Mycobacterium tuberculosis</span>
    Research Article | Host-Microbe Biology
    Vitamin A Metabolism by Dendritic Cells Triggers an Antimicrobial Response against Mycobacterium tuberculosis

    Tuberculosis (TB) is the leading cause of death by a single infectious agent worldwide. One factor that contributes to the success of the microbe is the deficiency in immunomodulatory nutrients, such as vitamin A (retinol), which are prevalent in areas where TB is endemic. Clinical trials show that restoration of systemic retinol levels in active TB patients is ineffective in mitigating the disease; however, laboratory studies...

    Elliot W. Kim, Avelino De Leon, Zhichun Jiang, Roxana A. Radu, Adrian R. Martineau, Edward D. Chan, Xiyuan Bai, Wen-Lin Su, Dennis J. Montoya, Robert L. Modlin, Philip T. Liu
  • Open Access
    Macrophages and Dendritic Cells Are the Predominant Cells Infected in Measles in Humans
    Editor's Pick Research Article | Host-Microbe Biology
    Macrophages and Dendritic Cells Are the Predominant Cells Infected in Measles in Humans

    We have brought together a unique collection of 23 human cases of measles infection and studied the types of cells that are infected. This work has not been done with modern technologies such as double labeling with antibodies and confocal microscopy in human cases primarily due to the fact that it is difficult to obtain the material because, fortunately, measles is fatal in only a very small fraction of infected patients. During the...

    Ingrid V. Allen, Stephen McQuaid, Rosana Penalva, Martin Ludlow, W. Paul Duprex, Bertus K. Rima
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