COVID-19
Research ArticleAntibody Response against SARS-CoV-2 and Seasonal Coronaviruses in Nonhospitalized COVID-19 PatientsThere is strong interest in the nature of the neutralizing antibody response against SARS-CoV-2 in infected individuals. For vaccine development, it is especially important which antibodies confer protection against SARS-CoV-2, if there is a phenomenon called antibody-dependent enhancement (ADE) of infection, and if there is cross-protection by antibodies directed against seasonal coronaviruses.
Perspective | Clinical Science and EpidemiologyTuberculosis under the Influence of COVID-19 Lockdowns: Lessons from Tehran, IranThis study investigates the short-term effects of the coronavirus disease 2019 (COVID-19) pandemic lockdown on tracing and detection of tuberculosis (TB) patients in Tehran, Iran. Results of this study have demonstrated that due to the significant decrease in the identification of patients with suspected TB during the COVID-19 outbreak in Tehran, it is imperative that patients with suspected TB be tracked and diagnosed more quickly to...
Research Article | Clinical Science and EpidemiologyMolecular Evolution of Human Coronavirus 229E in Hong Kong and a Fatal COVID-19 Case Involving Coinfection with a Novel Human Coronavirus 229E GenogroupSince its first appearance in the 1960s, the genetic diversity and evolution of human coronavirus 229E (HCoV-229E) have been relatively understudied. In this study, we report a fatal case of COVID-19 coinfected with HCoV-229E in Hong Kong.
Research Article | Clinical Science and EpidemiologySeroprevalence of SARS-CoV-2 Antibodies in Children and Adults in St. Louis, Missouri, USAThis study determined the percentages of both children and adult samples from the greater St. Louis metropolitan area who had antibodies to SARS-CoV-2 in late April to early May 2020.
Observation | Clinical Science and EpidemiologyAn Observational Laboratory-Based Assessment of SARS-CoV-2 Molecular Diagnostics in Benin, Western AfricaMonths after the start of the COVID-19 pandemic, case numbers from Africa are surprisingly low, potentially because the number of SARS-CoV-2 tests performed in Africa is lower than in other regions. Here, we show an overload of COVID-19-related diagnostics in the central laboratory of Benin, Western Africa, with a stagnating average number of positive samples irrespective of daily sample counts.
Research Article | Clinical Science and EpidemiologyConserved Genomic Terminals of SARS-CoV-2 as Coevolving Functional Elements and Potential Therapeutic TargetsThe CoV disease 2019 (COVID-19) infectious disease outbreak is having a dramatic global effect on public health and the economy. As of October 2020, SARS-CoV-2 has been detected in over 189 countries, has infected over 40 million people, and is responsible for more than 1 million deaths.
Research Article | Clinical Science and EpidemiologyDaily Viral Kinetics and Innate and Adaptive Immune Response Assessment in COVID-19: a Case SeriesThis work is particularly important because it simultaneously assessed the virology, immunology, and clinical presentation of the same subjects, whereas other studies assess these separately. We describe the detailed viral and immune profiles of the first five patients infected by SARS-CoV-2 and quarantined in Geneva, Switzerland. Viral loads peaked at the very beginning of the disease, and infectious virus was shed only during the...
Research Article | Clinical Science and EpidemiologyA Genome Epidemiological Study of SARS-CoV-2 Introduction into JapanThis study aimed to evaluate the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) genome sequences from COVID-19 cases and to characterize their genealogical networks to demonstrate possible routes of spread in Japan. We found that there were at least two distinct SARS-CoV-2 introductions into Japan, initially from China and subsequently from other countries, including Europe. Our findings can help understand how SARS-CoV-2...
Observation | Clinical Science and EpidemiologyEffectiveness of Face Masks in Preventing Airborne Transmission of SARS-CoV-2Airborne simulation experiments showed that cotton masks, surgical masks, and N95 masks provide some protection from the transmission of infective SARS-CoV-2 droplets/aerosols; however, medical masks (surgical masks and even N95 masks) could not completely block the transmission of virus droplets/aerosols even when sealed.
Research Article | Clinical Science and EpidemiologyDescriptive, Retrospective Study of the Clinical Characteristics of Asymptomatic COVID-19 PatientsAsymptomatic transmission of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is a potential problem for pandemic control through public health strategies. Our results demonstrate that asymptomatic COVID-19 patients have better outcomes than symptomatic patients. This may have been due to more active cellular immune responses and normal liver function. Since asymptomatic patients have no clinical symptoms which can easily...