colorectal cancer
Research Article | Host-Microbe BiologyThe Polyamine Spermidine Modulates the Production of the Bacterial Genotoxin ColibactinColibactin-producing Escherichia coli strains are associated with cancerous and precancerous colorectal tissues and are suspected of promoting colorectal carcinogenesis. In this study, we describe a new interplay between the synthesis of the genotoxin colibactin and the polyamine spermidine. Polyamines are highly abundant in cancer tissue and are associated with cell...
Resource Report | Host-Microbe BiologyFusoPortal: an Interactive Repository of Hybrid MinION-Sequenced Fusobacterium Genomes Improves Gene Identification and CharacterizationIn this report, we describe a hybrid MinION whole-genome sequencing pipeline and the genomic characteristics of the first eight Fusobacterium strains deposited in the FusoPortal database. This collection of highly accurate and complete genomes drastically improves upon previous multicontig assemblies by correcting and newly identifying a significant number of open reading frames. We believe that the availability of this...
Resource Report | Host-Microbe BiologyFusobacterium Genomics Using MinION and Illumina Sequencing Enables Genome Completion and CorrectionFusobacterium spp. are Gram-negative, oral bacteria that are increasingly associated with human pathologies as diverse as periodontitis, preterm birth, and colorectal cancer. While a recent surge in F. nucleatum research has increased our understanding of this human pathogen, a lack of complete genomes has hindered the identification and characterization of...
Minireview | Host-Microbe BiologyMetabolic and Community Synergy of Oral Bacteria in Colorectal Cancer
Editor's Pick Research Article | Host-Microbe BiologyManipulation of the Gut Microbiota Reveals Role in Colon TumorigenesisMounting evidence indicates that alterations to the gut microbiota, the complex community of bacteria that inhabits the gastrointestinal tract, are strongly associated with the development of colorectal cancer. We used antibiotic perturbations to a murine model of inflammation-driven colon cancer to generate eight starting communities that resulted in various severities of tumorigenesis. Furthermore, we were able to quantitatively...