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colonization resistance

  • Open Access
    The Gut Microbiota Is Associated with Clearance of <span class="named-content genus-species" id="named-content-1">Clostridium difficile</span> Infection Independent of Adaptive Immunity
    Research Article | Host-Microbe Biology
    The Gut Microbiota Is Associated with Clearance of Clostridium difficile Infection Independent of Adaptive Immunity

    Clostridium difficile infection is a major cause of morbidity and mortality in hospitalized patients in the United States. Currently, the role of the adaptive immune response in modulating levels of C. difficile colonization is unresolved. This work suggests that the indigenous gut microbiota is a...

    Jhansi L. Leslie, Kimberly C. Vendrov, Matthew L. Jenior, Vincent B. Young
  • Open Access
    <em>Clostridium difficile</em> Alters the Structure and Metabolism of Distinct Cecal Microbiomes during Initial Infection To Promote Sustained Colonization
    Research Article | Host-Microbe Biology
    Clostridium difficile Alters the Structure and Metabolism of Distinct Cecal Microbiomes during Initial Infection To Promote Sustained Colonization

    Clostridium difficile has become the most common single cause of hospital-acquired infection over the last decade in the United States. Colonization resistance to the nosocomial pathogen is primarily provided by the gut microbiota, which is also involved in clearing the infection as the community recovers from perturbation. As distinct antibiotics are associated with...

    Matthew L. Jenior, Jhansi L. Leslie, Vincent B. Young, Patrick D. Schloss
  • Open Access
    Antibiotic-Induced Alterations of the Gut Microbiota Alter Secondary Bile Acid Production and Allow for <span class="named-content genus-species" id="named-content-1">Clostridium difficile</span> Spore Germination and Outgrowth in the Large Intestine
    Research Article | Host-Microbe Biology
    Antibiotic-Induced Alterations of the Gut Microbiota Alter Secondary Bile Acid Production and Allow for Clostridium difficile Spore Germination and Outgrowth in the Large Intestine

    Antibiotics alter the gastrointestinal microbiota, allowing for Clostridium difficile infection, which is a significant public health problem. Changes in the structure of the gut microbiota alter the metabolome, specifically the production of secondary bile acids. Specific bile acids are able to initiate C...

    Casey M. Theriot, Alison A. Bowman, Vincent B. Young
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