collateral sensitivity
Commentary | Therapeutics and PreventionmSphere of Influence: Evolutionary Strategies To Sensitize Drug-Resistant PathogensRebecca S. Shapiro studies antimicrobial resistance and genetic interaction networks. In this mSphere of Influence article, she reflects on how the papers “Bacterial evolution of antibiotic hypersensitivity” by Lázár et al. (V. Lázár, G. Pal Singh, R. Spohn, I.
Research Article | Molecular Biology and PhysiologyOXA-48-Mediated Ceftazidime-Avibactam Resistance Is Associated with Evolutionary Trade-OffsThe recent introduction of novel β-lactam/β-lactamase inhibitor combinations like ceftazidime-avibactam has increased our ability to treat infections caused by multidrug-resistant Gram-negative bacteria, including carbapenemase-producing Enterobacterales. However, the increasing number of cases of reported resistance to ceftazidime-avibactam is a concern. OXA-48 is a carbapenemase that has no significant effect on ceftazidime,...