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capsular polysaccharide

  • Open Access
    Novel Insights and Features of the NDM-5-Producing <span class="named-content genus-species" id="named-content-1">Escherichia coli</span> Sequence Type 167 High-Risk Clone
    Editor's Pick Research Article | Clinical Science and Epidemiology
    Novel Insights and Features of the NDM-5-Producing Escherichia coli Sequence Type 167 High-Risk Clone

    Global dissemination of some E. coli high-risk clones has been described in the last decades. The most widespread was the ST131 clone, associated with extended-spectrum-beta-lactamase (ESBL) production. Genomics of ST131 demonstrated that one clade within the ST emerged in the early 2000s, followed by a rapid, global expansion. The...

    Aurora Garcia-Fernandez, Laura Villa, Giulia Bibbolino, Alessia Bressan, Maria Trancassini, Valeria Pietropaolo, Mario Venditti, Guido Antonelli, Alessandra Carattoli
  • Open Access
    Multilaboratory Comparison of Pneumococcal Multiplex Immunoassays Used in Immunosurveillance of <span class="named-content genus-species" id="named-content-1">Streptococcus pneumoniae</span> across Europe
    Research Article | Clinical Science and Epidemiology
    Multilaboratory Comparison of Pneumococcal Multiplex Immunoassays Used in Immunosurveillance of Streptococcus pneumoniae across Europe

    Serology of Streptococcus pneumoniae is challenging due to existence of multiple clinically relevant serotypes and the introduction of multivalent vaccines in national immunization programs. Multiplex immunoassays (MIAs) are applied as high-throughput cost-effective methods for serosurveillance, and yet laboratories use their own protocols. The aims of this study were...

    Bob Meek, Nina Ekström, Bjørn Kantsø, Rachael Almond, Jamie Findlow, Jenna F. Gritzfeld, Charlotte Sværke Jørgensen, Karl Ljungberg, Fredrik Atterfelt, Manou R. Batstra, Kevin Andeweg, Ben A. W. de Jong, Harry E. Prince, Mary Lapé-Nixon, Pieter G. M. Gageldonk, Irina Tcherniaeva, Ingeborg Aaberge, Tove Karin Herstad, Merit Melin, Ger T. Rijkers, Guy A. Berbers
    and on behalf of the EU Pneumo Multiplex Assay Consortium
  • Open Access
    Glycoconjugates: What It Would Take To Master These Well-Known yet Little-Understood Immunogens for Vaccine Development
    Perspective | Therapeutics and Prevention
    Glycoconjugates: What It Would Take To Master These Well-Known yet Little-Understood Immunogens for Vaccine Development

    Glycoconjugate vaccines are a critical component of the medical arsenal against infectious diseases. This established field continues, however, to experience failures in the clinic. The lack of fundamental understanding of factors controlling clinical efficacy of glycoconjugate vaccines is discussed while key parameters demanding focused and collaborative research are identified.

    Fikri Avci, Francesco Berti, Peter Dull, John Hennessey, Viliam Pavliak, A. Krishna Prasad, Willie Vann, Michael Wacker, Olivier Marcq
  • Open Access
    The Buoyancy of <em>Cryptococcus neoformans</em> Is Affected by Capsule Size
    Research Article | Host-Microbe Biology
    The Buoyancy of Cryptococcus neoformans Is Affected by Capsule Size

    The buoyancy of a microbial cell is an important physical characteristic that may affect its transportability in fluids and interactions with tissues during infection. The polysaccharide capsule surrounding C. neoformans is required for infection and dissemination in the host. Our results indicate that the capsule has a significant effect on reducing cryptococcal cell...

    Raghav Vij, Radames J. B. Cordero, Arturo Casadevall
  • Open Access
    A Predicted Mannoprotein Participates in <span class="named-content genus-species" id="named-content-1">Cryptococcus gattii</span> Capsular Structure
    Research Article | Host-Microbe Biology
    A Predicted Mannoprotein Participates in Cryptococcus gattii Capsular Structure

    Cryptococcus gattii has the ability to escape from the host’s immune system through poorly understood mechanisms and can lead to the death of healthy individuals. The role of mannoproteins in C. gattii pathogenicity is not completely understood. The present work characterized a protein, Kpr1, that...

    Julia Catarina Vieira Reuwsaat, Heryk Motta, Ane Wichine Acosta Garcia, Carolina Bettker Vasconcelos, Bárbara Machado Marques, Natália Kronbauer Oliveira, Jéssica Rodrigues, Patrícia Aline Gröhns Ferrareze, Susana Frases, William Lopes, Vanessa Abreu Barcellos, Eamim Daidrê Squizani, Jorge André Horta, Augusto Schrank, Marcio Lourenço Rodrigues, Charley Christian Staats, Marilene Henning Vainstein, Lívia Kmetzsch
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