capsular polysaccharide
Editor's Pick Research Article | Clinical Science and EpidemiologyNovel Insights and Features of the NDM-5-Producing Escherichia coli Sequence Type 167 High-Risk CloneGlobal dissemination of some E. coli high-risk clones has been described in the last decades. The most widespread was the ST131 clone, associated with extended-spectrum-beta-lactamase (ESBL) production. Genomics of ST131 demonstrated that one clade within the ST emerged in the early 2000s, followed by a rapid, global expansion. The...
Research Article | Clinical Science and EpidemiologyMultilaboratory Comparison of Pneumococcal Multiplex Immunoassays Used in Immunosurveillance of Streptococcus pneumoniae across EuropeSerology of Streptococcus pneumoniae is challenging due to existence of multiple clinically relevant serotypes and the introduction of multivalent vaccines in national immunization programs. Multiplex immunoassays (MIAs) are applied as high-throughput cost-effective methods for serosurveillance, and yet laboratories use their own protocols. The aims of this study were...
Perspective | Therapeutics and PreventionGlycoconjugates: What It Would Take To Master These Well-Known yet Little-Understood Immunogens for Vaccine DevelopmentGlycoconjugate vaccines are a critical component of the medical arsenal against infectious diseases. This established field continues, however, to experience failures in the clinic. The lack of fundamental understanding of factors controlling clinical efficacy of glycoconjugate vaccines is discussed while key parameters demanding focused and collaborative research are identified.
Research Article | Host-Microbe BiologyThe Buoyancy of Cryptococcus neoformans Is Affected by Capsule SizeThe buoyancy of a microbial cell is an important physical characteristic that may affect its transportability in fluids and interactions with tissues during infection. The polysaccharide capsule surrounding C. neoformans is required for infection and dissemination in the host. Our results indicate that the capsule has a significant effect on reducing cryptococcal cell...
Research Article | Host-Microbe BiologyA Predicted Mannoprotein Participates in Cryptococcus gattii Capsular StructureCryptococcus gattii has the ability to escape from the host’s immune system through poorly understood mechanisms and can lead to the death of healthy individuals. The role of mannoproteins in C. gattii pathogenicity is not completely understood. The present work characterized a protein, Kpr1, that...