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Candida albicans

  • Open Access
    An Intragenic Recombination Event Generates a Snf4-Independent Form of the Essential Protein Kinase Snf1 in <span class="named-content genus-species" id="named-content-1">Candida albicans</span>
    Research Article | Molecular Biology and Physiology
    An Intragenic Recombination Event Generates a Snf4-Independent Form of the Essential Protein Kinase Snf1 in Candida albicans

    Genomic alterations, including different types of recombination events, facilitate the generation of genetically altered variants and enable the pathogenic yeast Candida albicans to adapt to stressful conditions encountered in its human host. Here, we show that a specific recombination event between two 8-bp direct repeats within the coding sequence of the SNF1...

    Austin Mottola, Joachim Morschhäuser
  • Open Access
    Roles of the Transcription Factors Sfl2 and Efg1 in White-Opaque Switching in a/α Strains of <span class="named-content genus-species" id="named-content-1">Candida albicans</span>
    Editor's Pick Research Article | Molecular Biology and Physiology
    Roles of the Transcription Factors Sfl2 and Efg1 in White-Opaque Switching in a/α Strains of Candida albicans

    More than 95% of Candida albicans strains isolated from humans are MTLa/α, and approximately a third of these can undergo the white-to-opaque transition. Therefore, besides being a requirement for MTL-homozygous strains to mate, the opaque phenotype very likely plays a role in the commensalism and pathogenesis of nonmating, a...

    Yang-Nim Park, Kayla Conway, Thomas P. Conway, Karla J. Daniels, David R. Soll
  • Open Access
    A Novel Virulence Phenotype Rapidly Assesses <em>Candida</em> Fungal Pathogenesis in Healthy and Immunocompromised <em>Caenorhabditis elegans</em> Hosts
    Research Article | Host-Microbe Biology
    A Novel Virulence Phenotype Rapidly Assesses Candida Fungal Pathogenesis in Healthy and Immunocompromised Caenorhabditis elegans Hosts

    Opportunistic pathogens are commensals capable of causing disease and are serious threats to human health. It is critical to understand the mechanisms and host contexts under which opportunistic pathogens become virulent. In this work, we present a novel assay to quickly and quantitatively measure pathogen virulence in healthy and immunocompromised nematode hosts. We found that Candida species, one of the most prominent fungal...

    Dorian J. Feistel, Rema Elmostafa, Nancy Nguyen, McKenna Penley, Levi Morran, Meleah A. Hickman
  • Open Access
    <span class="named-content genus-species" id="named-content-1">Candida glabrata</span> Has No Enhancing Role in the Pathogenesis of <em>Candida</em>-Associated Denture Stomatitis in a Rat Model
    Research Article | Host-Microbe Biology
    Candida glabrata Has No Enhancing Role in the Pathogenesis of Candida-Associated Denture Stomatitis in a Rat Model

    Many denture wearers suffer from Candida-associated denture stomatitis (DS), a fungal infection of the hard palate in contact with dentures. Biofilm formation by Candida albicans on denture/palate surfaces is considered a central process in the infection onset. Although Candida glabrata is...

    Junko Yano, Alika Yu, Paul L. Fidel, Mairi C. Noverr
  • Open Access
    MAP Kinase Regulation of the <em>Candida albicans</em> Pheromone Pathway
    Research Article | Molecular Biology and Physiology
    MAP Kinase Regulation of the Candida albicans Pheromone Pathway

    MAP kinases and their regulators are critical components of eukaryotic signaling pathways implicated in normal cell behavior as well as abnormal behaviors linked to diseases such as cancer. The mating pathway of the yeast Saccharomyces cerevisiae was central in establishing the MAP kinase paradigm....

    Golnaz Rastghalam, Raha Parvizi Omran, Masoumeh Alizadeh, Debrah Fulton, Jaideep Mallick, Malcolm Whiteway
  • Open Access
    Identification of Recessive Lethal Alleles in the Diploid Genome of a <span class="named-content genus-species" id="named-content-1">Candida albicans</span> Laboratory Strain Unveils a Potential Role of Repetitive Sequences in Buffering Their Deleterious Impact
    Research Article | Host-Microbe Biology
    Identification of Recessive Lethal Alleles in the Diploid Genome of a Candida albicans Laboratory Strain Unveils a Potential Role of Repetitive Sequences in Buffering Their Deleterious Impact

    Candida albicans is a major fungal pathogen, whose mode of reproduction is mainly clonal. Its genome is highly tolerant to rearrangements, in particular loss of heterozygosity events, known to unmask recessive lethal and deleterious alleles in heterozygous diploid organisms such as C. albicans. By...

    Timea Marton, Adeline Feri, Pierre-Henri Commere, Corinne Maufrais, Christophe d’Enfert, Melanie Legrand
  • Open Access
    A CRISPR Interference Platform for Efficient Genetic Repression in <em>Candida albicans</em>
    Editor's Pick Research Article | Synthetic Biology
    A CRISPR Interference Platform for Efficient Genetic Repression in Candida albicans

    Fungal pathogens are an increasingly important cause of human disease and mortality, and Candida albicans is among the most common causes of fungal disease. Studying this important fungal pathogen requires a comprehensive genetic toolkit to establish how different genetic factors play roles in the biology and virulence of this pathogen. Here, we developed a CRISPR-...

    Lauren Wensing, Jehoshua Sharma, Deeva Uthayakumar, Yannic Proteau, Alejandro Chavez, Rebecca S. Shapiro
  • Open Access
    Implementation of a CRISPR-Based System for Gene Regulation in <em>Candida albicans</em>
    Editor's Pick Research Article | Molecular Biology and Physiology
    Implementation of a CRISPR-Based System for Gene Regulation in Candida albicans

    CRISPR technology is a new and efficient way to edit genomes, but it is also an appealing way to regulate gene expression. We have implemented CRISPR as a gene expression platform in Candida albicans using fusions between a Cas9 inactive enzyme and specific repressors or activators and demonstrated its functionality. This will allow future manipulation of complex...

    Elvira Román, Ioana Coman, Daniel Prieto, Rebeca Alonso-Monge, Jesús Pla
  • Open Access
    The Vacuolar Ca<sup>2+</sup> ATPase Pump Pmc1p Is Required for <span class="named-content genus-species" id="named-content-1">Candida albicans</span> Pathogenesis
    Research Article | Molecular Biology and Physiology
    The Vacuolar Ca2+ ATPase Pump Pmc1p Is Required for Candida albicans Pathogenesis

    Maintenance of Ca2+ homeostasis is important for fungal cells to respond to a multitude of stresses, as well as antifungal treatment, and for virulence in animal models. Here, we demonstrate that a P-type ATPase, Pmc1p, is required for Candida albicans to respond to a variety of stresses...

    Arturo Luna-Tapia, Christian DeJarnette, Emily Sansevere, Parker Reitler, Arielle Butts, Kirk E. Hevener, Glen E. Palmer
  • Open Access
    Repurposing Pilocarpine Hydrochloride for Treatment of <span class="named-content genus-species" id="named-content-1">Candida albicans</span> Infections
    Research Article | Therapeutics and Prevention
    Repurposing Pilocarpine Hydrochloride for Treatment of Candida albicans Infections

    Candida albicans is the most common human fungal pathogen with an estimated crude mortality rate of 40%. The ability of the organism to switch from the yeast to hyphal form and produce biofilms are important virulence factors. C. albicans infections are combatted by the host immune system. However...

    Christopher Nile, Monica Falleni, Daniela Cirasola, Abeer Alghamdi, Oliver F. Anderson, Christopher Delaney, Gordon Ramage, Emerenziana Ottaviano, Delfina Tosi, Gaetano Bulfamante, Giulia Morace, Elisa Borghi

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