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Candida albicans

  • Open Access
    Comparative Evaluations of the Pathogenesis of <span class="named-content genus-species" id="named-content-1">Candida auris</span> Phenotypes and <span class="named-content genus-species" id="named-content-2">Candida albicans</span> Using Clinically Relevant Murine Models of Infections
    Research Article | Host-Microbe Biology
    Comparative Evaluations of the Pathogenesis of Candida auris Phenotypes and Candida albicans Using Clinically Relevant Murine Models of Infections

    The newly emerged Candida species C. auris has been associated with an exponential rise in invasive disease in health care facilities worldwide with a mortality rate approaching 60%. C. auris exhibits a high level of transmissibility, multidrug resistance, and persistence in hospital...

    Taissa Vila, Daniel Montelongo-Jauregui, Hussian Ahmed, Taanya Puthran, Ahmed S. Sultan, Mary Ann Jabra-Rizk
  • Open Access
    Molecular Elucidation of Riboflavin Production and Regulation in <span class="named-content genus-species" id="named-content-1">Candida albicans</span>, toward a Novel Antifungal Drug Target
    Editor's Pick Research Article | Host-Microbe Biology
    Molecular Elucidation of Riboflavin Production and Regulation in Candida albicans, toward a Novel Antifungal Drug Target

    Candida albicans is an important fungal pathogen causing common superficial infections as well as invasive diseases with an extremely high morbidity and mortality. Antifungal therapies are limited in efficiency and availability. In this research, we describe the regulation of riboflavin production in C....

    Liesbeth Demuyser, Ilse Palmans, Paul Vandecruys, Patrick Van Dijck
  • Open Access
    Bacteria Modify <em>Candida albicans</em> Hypha Formation, Microcolony Properties, and Survival within Macrophages
    Research Article | Host-Microbe Biology
    Bacteria Modify Candida albicans Hypha Formation, Microcolony Properties, and Survival within Macrophages

    Candida albicans is the predominant fungus colonizing the oral cavity that can have both synergistic and antagonistic interactions with other bacteria. Interkingdom polymicrobial associations modify fungal pathogenicity and are believed to increase microbial resistance to innate immunity. However, it is not known how these interactions alter fungal survival during...

    Ornella Salvatori, Rohitashw Kumar, Sarah Metcalfe, Margaret Vickerman, Jason G. Kay, Mira Edgerton
  • Open Access
    Sho1p Connects Glycolysis to Ras1-cAMP Signaling and Is Required for Microcolony Formation in <span class="named-content genus-species" id="named-content-1">Candida albicans</span>
    Research Article | Molecular Biology and Physiology
    Sho1p Connects Glycolysis to Ras1-cAMP Signaling and Is Required for Microcolony Formation in Candida albicans

    C. albicans microcolonies form extensive hyphal structures that enhance surface adherence and penetrate underlying tissues to promote fungal infections. This study examined the environmental conditions that promote microcolony formation and how these signals are relayed, in order to disrupt signaling and reduce pathogenesis. We found that a membrane-localized protein...

    Rohitashw Kumar, Malabika Maulik, Ruvini U. Pathirana, Paul J. Cullen, Mira Edgerton
  • Open Access
    Dihydrofolate Reductase Is a Valid Target for Antifungal Development in the Human Pathogen <em>Candida albicans</em>
    Research Article | Molecular Biology and Physiology
    Dihydrofolate Reductase Is a Valid Target for Antifungal Development in the Human Pathogen Candida albicans

    The folate biosynthetic pathway is a promising and understudied source for novel antifungals. Even dihydrofolate reductase (DHFR), a well-characterized and historically important drug target, has not been conclusively validated as an antifungal target. Here, we demonstrate that repression of DHFR inhibits growth of Candida albicans, a major human fungal pathogen....

    Christian DeJarnette, Arturo Luna-Tapia, Leanna R. Estredge, Glen E. Palmer
  • Open Access
    Host-Induced Genome Instability Rapidly Generates Phenotypic Variation across <span class="named-content genus-species" id="named-content-1">Candida albicans</span> Strains and Ploidy States
    Research Article | Host-Microbe Biology
    Host-Induced Genome Instability Rapidly Generates Phenotypic Variation across Candida albicans Strains and Ploidy States

    Candida albicans is an opportunistic fungal pathogen of humans. The ability to generate genetic variation is essential for adaptation and is a strategy that C. albicans and other fungal pathogens use to change their genome size. Stressful environments, including the host, induce...

    Amanda C. Smith, Meleah A. Hickman
  • Open Access
    Oxadiazole-Containing Macrocyclic Peptides Potentiate Azole Activity against Pathogenic <em>Candida</em> Species
    Editor's Pick Observation | Therapeutics and Prevention
    Oxadiazole-Containing Macrocyclic Peptides Potentiate Azole Activity against Pathogenic Candida Species

    Fungal infections, such as those caused by pathogenic Candida species, pose a serious threat to human health. Treating these infections relies heavily on the use of azole antifungals; however, resistance to these drugs develops readily, demanding novel therapeutic strategies. This study characterized the antifungal activity of a series of molecules that possess unique chemical attributes and the ability to traverse cellular...

    Nicole M. Revie, Nicole Robbins, Luke Whitesell, John R. Frost, Solomon D. Appavoo, Andrei K. Yudin, Leah E. Cowen
  • Open Access
    Metabolic Reprogramming in the Opportunistic Yeast <span class="named-content genus-species" id="named-content-1">Candida albicans</span> in Response to Hypoxia
    Editor's Pick Research Article | Molecular Biology and Physiology
    Metabolic Reprogramming in the Opportunistic Yeast Candida albicans in Response to Hypoxia

    A critical aspect of cell fitness is the ability to sense and adapt to variations in oxygen levels in their local environment. Candida albicans is an opportunistic yeast that is the most prevalent human fungal pathogen. While hypoxia is the predominant condition that C. albicans encounters in most...

    Anaïs Burgain, Faiza Tebbji, Inès Khemiri, Adnane Sellam
  • Open Access
    Nucleotide Excision Repair Protein Rad23 Regulates Cell Virulence Independent of Rad4 in <span class="named-content genus-species" id="named-content-1">Candida albicans</span>
    Research Article | Host-Microbe Biology
    Nucleotide Excision Repair Protein Rad23 Regulates Cell Virulence Independent of Rad4 in Candida albicans

    Candida albicans remains a significant threat to the lives of immunocompromised people. An understanding of the virulence and infection ability of C. albicans cells in the mammalian host may help with clinical treatment and drug discovery. The DNA damage response pathway is closely related to...

    Jia Feng, Shuangyan Yao, Yansong Dong, Jing Hu, Malcolm Whiteway, Jinrong Feng
  • Open Access
    <em>EFG1</em> Mutations, Phenotypic Switching, and Colonization by Clinical a/α Strains of <span class="named-content genus-species" id="named-content-1">Candida albicans</span>
    Research Article | Molecular Biology and Physiology
    EFG1 Mutations, Phenotypic Switching, and Colonization by Clinical a/α Strains of Candida albicans

    Close to half of a collection of 27 clinical a/α isolates of Candida albicans underwent white-to-opaque switching. Complementation experiments revealed that while approximately half of the a/α switchers were due to EFG1 mutations, the remaining half were due to mutations in other genes. In addition, the results of competition...

    Yang-Nim Park, Kayla Conway, Claude Pujol, Karla J. Daniels, David R. Soll

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