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Candida

  • Open Access
    Triazole Evolution of <span class="named-content genus-species" id="named-content-1">Candida parapsilosis</span> Results in Cross-Resistance to Other Antifungal Drugs, Influences Stress Responses, and Alters Virulence in an Antifungal Drug-Dependent Manner
    Research Article | Host-Microbe Biology
    Triazole Evolution of Candida parapsilosis Results in Cross-Resistance to Other Antifungal Drugs, Influences Stress Responses, and Alters Virulence in an Antifungal Drug-Dependent Manner

    Candida parapsilosis causes life-threatening fungal infections. In the last 2 decades, the increasing number of azole-resistant C. parapsilosis clinical isolates has been attributable to the overuse and misuse of fluconazole, the first-line antifungal agent most commonly used in several countries....

    Csaba Papp, Flóra Bohner, Katica Kocsis, Mónika Varga, András Szekeres, László Bodai, Jesse R. Willis, Toni Gabaldón, Renáta Tóth, Joshua D. Nosanchuk, Csaba Vágvölgyi, Attila Gácser
  • Open Access
    Oxadiazole-Containing Macrocyclic Peptides Potentiate Azole Activity against Pathogenic <em>Candida</em> Species
    Editor's Pick Observation | Therapeutics and Prevention
    Oxadiazole-Containing Macrocyclic Peptides Potentiate Azole Activity against Pathogenic Candida Species

    Fungal infections, such as those caused by pathogenic Candida species, pose a serious threat to human health. Treating these infections relies heavily on the use of azole antifungals; however, resistance to these drugs develops readily, demanding novel therapeutic strategies. This study characterized the antifungal activity of a series of molecules that possess unique chemical attributes and the ability to traverse cellular...

    Nicole M. Revie, Nicole Robbins, Luke Whitesell, John R. Frost, Solomon D. Appavoo, Andrei K. Yudin, Leah E. Cowen
  • Open Access
    <span class="named-content genus-species" id="named-content-1">Candida albicans</span> Impacts <span class="named-content genus-species" id="named-content-2">Staphylococcus aureus</span> Alpha-Toxin Production via Extracellular Alkalinization
    Research Article | Host-Microbe Biology
    Candida albicans Impacts Staphylococcus aureus Alpha-Toxin Production via Extracellular Alkalinization

    Candida albicans and Staphylococcus aureus are commonly coisolated from central venous catheters and deep-seated infections, including intra-abdominal sepsis. Thus, they represent a significant cause of nosocomial morbidity and mortality. Yet how these organisms behave in the context of...

    Olivia A. Todd, Mairi C. Noverr, Brian M. Peters
  • Open Access
    Experimental Mouse Models of Disseminated <span class="named-content genus-species" id="named-content-1">Candida auris</span> Infection
    Research Article | Therapeutics and Prevention
    Experimental Mouse Models of Disseminated Candida auris Infection

    In the last decade, Candida auris has emerged globally as a multidrug‐resistant fungal pathogen. Although C. auris was initially isolated from the external ear canal, it can cause outbreaks of invasive infections with very high mortality and comorbidities. Recent reports highlight the ongoing...

    Hong Xin, Farhan Mohiuddin, Jensen Tran, Abby Adams, Karen Eberle
  • Open Access
    Combined Antifungal Resistance and Biofilm Tolerance: the Global Threat of <span class="named-content genus-species" id="named-content-1">Candida auris</span>
    Minireview | Therapeutics and Prevention
    Combined Antifungal Resistance and Biofilm Tolerance: the Global Threat of Candida auris

    The enigmatic yeast Candida auris has emerged over the last decade and rapidly penetrated our consciousness. The global threat from this multidrug-resistant yeast has generated a call to arms from within the medical mycology community. Over the past decade, our understanding of how this yeast has spread globally, its clinical importance, and how it tolerates and...

    Ryan Kean, Gordon Ramage
  • Open Access
    Titrating Gene Function in the Human Fungal Pathogen <span class="named-content genus-species" id="named-content-1">Candida albicans</span> through Poly-Adenosine Tract Insertion
    Research Article | Molecular Biology and Physiology
    Titrating Gene Function in the Human Fungal Pathogen Candida albicans through Poly-Adenosine Tract Insertion

    Investigating a protein’s functional importance at the whole-organism level usually involves altering its expression level or its specific activity and observing the consequences with respect to physiology or phenotype. Several approaches designed to partially or completely abolish the function of a gene, including its deletion from the genome and the use of systems that facilitate conditional expression, have been widely applied....

    Helene Tournu, Arielle Butts, Glen E. Palmer
  • Open Access
    Plasmid-Based CRISPR-Cas9 Gene Editing in Multiple <em>Candida</em> Species
    Editor's Pick Research Article | Molecular Biology and Physiology
    Plasmid-Based CRISPR-Cas9 Gene Editing in Multiple Candida Species

    Candida species are a major cause of infection worldwide. The species associated with infection vary with geographical location and with patient population. Infection with Candida tropicalis is particularly common in South America and Asia, and Candida parapsilosis infections are more...

    Lisa Lombardi, João Oliveira-Pacheco, Geraldine Butler
  • Open Access
    A CRISPR Interference Platform for Efficient Genetic Repression in <em>Candida albicans</em>
    Editor's Pick Research Article | Synthetic Biology
    A CRISPR Interference Platform for Efficient Genetic Repression in Candida albicans

    Fungal pathogens are an increasingly important cause of human disease and mortality, and Candida albicans is among the most common causes of fungal disease. Studying this important fungal pathogen requires a comprehensive genetic toolkit to establish how different genetic factors play roles in the biology and virulence of this pathogen. Here, we developed a CRISPR-...

    Lauren Wensing, Jehoshua Sharma, Deeva Uthayakumar, Yannic Proteau, Alejandro Chavez, Rebecca S. Shapiro
  • Open Access
    Transcriptome Assembly and Profiling of <em>Candida auris</em> Reveals Novel Insights into Biofilm-Mediated Resistance
    Editor's Pick Research Article | Therapeutics and Prevention
    Transcriptome Assembly and Profiling of Candida auris Reveals Novel Insights into Biofilm-Mediated Resistance

    Fungal infections represent an important cause of human morbidity and mortality, particularly if the fungi adhere to and grow on both biological and inanimate surfaces as communities of cells (biofilms). Recently, a previously unrecognized yeast, Candida auris, has emerged globally that has led to widespread concern due to the difficulty in treating it with existing...

    Ryan Kean, Christopher Delaney, Leighann Sherry, Andrew Borman, Elizabeth M. Johnson, Malcolm D. Richardson, Riina Rautemaa-Richardson, Craig Williams, Gordon Ramage
  • Open Access
    New CRISPR Mutagenesis Strategies Reveal Variation in Repair Mechanisms among Fungi
    Editor's Pick Research Article | Molecular Biology and Physiology
    New CRISPR Mutagenesis Strategies Reveal Variation in Repair Mechanisms among Fungi

    CRISPR-mediated genome engineering technologies have revolutionized genetic studies in a wide range of organisms. Here we describe new vectors and guide sequences for CRISPR mutagenesis in the important human fungal pathogens C. albicans and C. glabrata, as well as in the related yeasts...

    Valmik K. Vyas, G. Guy Bushkin, Douglas A. Bernstein, Matthew A. Getz, Magdalena Sewastianik, M. Inmaculada Barrasa, David P. Bartel, Gerald R. Fink

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