Campylobacter

  • Open Access
    <em>Campylobacter</em> Abundance in Breastfed Infants and Identification of a New Species in the Global Enterics Multicenter Study
    Research Article | Host-Microbe Biology
    Campylobacter Abundance in Breastfed Infants and Identification of a New Species in the Global Enterics Multicenter Study

    Campylobacter is the primary cause of bacterial diarrhea in the United States and can lead to the development of the postinfectious autoimmune neuropathy known as Guillain-Barré syndrome. Also, drug-resistant campylobacters are becoming a serious concern both locally and abroad. In low- and middle-income countries (LMICs), infection with Campylobacter is linked to high rates of morbidity, growth stunting, and mortality...

    Xiaoming Bian, Jolene M. Garber, Kerry K. Cooper, Steven Huynh, Jennifer Jones, Michael K. Mills, Daniel Rafala, Dilruba Nasrin, Karen L. Kotloff, Craig T. Parker, Sharon M. Tennant, William G. Miller, Christine M. Szymanski
  • Open Access
    Genomic Analysis of Emerging Florfenicol-Resistant <span class="named-content genus-species" id="named-content-1">Campylobacter coli</span> Isolated from the Cecal Contents of Cattle in the United States
    Research Article | Applied and Environmental Science
    Genomic Analysis of Emerging Florfenicol-Resistant Campylobacter coli Isolated from the Cecal Contents of Cattle in the United States

    Campylobacter is a leading cause of foodborne diarrheal illness worldwide, with more than one million cases each year in the United States alone. The global emergence of antimicrobial resistance in this pathogen has become a growing public health concern. Florfenicol-resistant (FFNr) Campylobacter has been very rare in the United States. In this study, we employed whole-genome sequencing to characterize 16...

    Shaohua Zhao, Sampa Mukherjee, Chih-Hao Hsu, Shenia Young, Cong Li, Heather Tate, Cesar A. Morales, Jovita Haro, Sutawee Thitaram, Glenn E. Tillman, Uday Dessai, Patrick McDermott
  • Open Access
    Enhanced Immunogenicity and Protective Efficacy of a <em>Campylobacter jejuni</em> Conjugate Vaccine Coadministered with Liposomes Containing Monophosphoryl Lipid A and QS-21
    Research Article | Therapeutics and Prevention
    Enhanced Immunogenicity and Protective Efficacy of a Campylobacter jejuni Conjugate Vaccine Coadministered with Liposomes Containing Monophosphoryl Lipid A and QS-21

    Campylobacter jejuni is a leading cause of diarrheal disease worldwide, and currently no preventative interventions are available. C. jejuni is an invasive mucosal pathogen that has a variety of polysaccharide structures on its surface, including a capsule. In phase 1 studies, a...

    Amritha Ramakrishnan, Nina M. Schumack, Christina L. Gariepy, Heather Eggleston, Gladys Nunez, Nereyda Espinoza, Monica Nieto, Rosa Castillo, Jesus Rojas, Andrea J. McCoy, Zoltan Beck, Gary R. Matyas, Carl R. Alving, Patricia Guerry, Frédéric Poly, Renee M. Laird
  • Open Access
    Novel Immunomodulatory Flagellin-Like Protein FlaC in <span class="named-content genus-species" id="named-content-1">Campylobacter jejuni</span> and Other <em>Campylobacterales</em>
    Research Article | Host-Microbe Biology
    Novel Immunomodulatory Flagellin-Like Protein FlaC in Campylobacter jejuni and Other Campylobacterales

    Flagellins not only are important for bacterial motility but are major bacterial proteins that can modulate host responses via Toll-like receptor 5 (TLR5) or other pattern recognition receptors. Campylobacterales colonizing the intestinal tracts of different host species harbor a gene coding for an unusual flagellin, FlaC, that is not involved in motility but is secreted and possesses a chimeric amino acid sequence composed of...

    Eugenia Faber, Eugenia Gripp, Sven Maurischat, Bernd Kaspers, Karsten Tedin, Sarah Menz, Aleksandra Zuraw, Olivia Kershaw, Ines Yang, Silke Rautenschlein, Christine Josenhans
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