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Caenorhabditis elegans

  • Open Access
    A Novel Virulence Phenotype Rapidly Assesses <em>Candida</em> Fungal Pathogenesis in Healthy and Immunocompromised <em>Caenorhabditis elegans</em> Hosts
    Research Article | Host-Microbe Biology
    A Novel Virulence Phenotype Rapidly Assesses Candida Fungal Pathogenesis in Healthy and Immunocompromised Caenorhabditis elegans Hosts

    Opportunistic pathogens are commensals capable of causing disease and are serious threats to human health. It is critical to understand the mechanisms and host contexts under which opportunistic pathogens become virulent. In this work, we present a novel assay to quickly and quantitatively measure pathogen virulence in healthy and immunocompromised nematode hosts. We found that Candida species, one of the most prominent fungal...

    Dorian J. Feistel, Rema Elmostafa, Nancy Nguyen, McKenna Penley, Levi Morran, Meleah A. Hickman
  • Open Access
    Intracellular Trafficking and Persistence of <span class="named-content genus-species" id="named-content-1">Acinetobacter baumannii</span> Requires Transcription Factor EB
    Research Article | Host-Microbe Biology
    Intracellular Trafficking and Persistence of Acinetobacter baumannii Requires Transcription Factor EB

    Adhesion is an initial and important step in Acinetobacter baumannii infections. However, the mechanism of entrance and persistence inside host cells is unclear and remains to be understood. In this study, we report that, in addition to its known role in host defense against Gram-positive bacterial infection, TFEB also plays an important role in the intracellular...

    Raquel Parra-Millán, David Guerrero-Gómez, Rafael Ayerbe-Algaba, Maria Eugenia Pachón-Ibáñez, Antonio Miranda-Vizuete, Jerónimo Pachón, Younes Smani
  • Open Access
    A High-Content, Phenotypic Screen Identifies Fluorouridine as an Inhibitor of Pyoverdine Biosynthesis and <span class="named-content genus-species" id="named-content-1">Pseudomonas aeruginosa</span> Virulence
    Research Article | Host-Microbe Biology
    A High-Content, Phenotypic Screen Identifies Fluorouridine as an Inhibitor of Pyoverdine Biosynthesis and Pseudomonas aeruginosa Virulence

    Despite intense research effort from scientists and the advent of the molecular age of biomedical research, many of the mechanisms that underlie pathogenesis are still understood poorly, if at all. The opportunistic human pathogen Pseudomonas aeruginosa causes a variety of soft tissue infections and is responsible for over 50,000 hospital-acquired infections per year...

    Daniel R. Kirienko, Alexey V. Revtovich, Natalia V. Kirienko
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