BLA

  • Open Access
    Induction of β-Lactamase Activity and Decreased β-Lactam Susceptibility by CO<sub>2</sub> in Clinical Bacterial Isolates
    Research Article | Clinical Science and Epidemiology
    Induction of β-Lactamase Activity and Decreased β-Lactam Susceptibility by CO2 in Clinical Bacterial Isolates

    β-Lactamase induction and concurrent β-lactam resistance in respiratory tract pathogens as a consequence of growth in a physiologically relevant level of CO2 are of clinical significance, particularly given the ubiquity of TEM and SHV β-lactamase genes in diverse bacterial pathogens. This is the first report of β-lactamase induction by 5% CO2.

    Nathan Mullen, Hugo Raposo, Polyxeni Gudis, Linsey Barker, Romney M. Humphries, Bryan H. Schmitt, Ryan F. Relich, Meghan May
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