beta-glucans

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    Dectin-1-Targeted Antifungal Liposomes Exhibit Enhanced Efficacy
    Editor's Pick Research Article | Therapeutics and Prevention
    Dectin-1-Targeted Antifungal Liposomes Exhibit Enhanced Efficacy

    The fungus Aspergillus fumigatus causes pulmonary invasive aspergillosis resulting in nearly 100,000 deaths each year. Patients are often treated with antifungal drugs such as amphotericin B (AmB) loaded into liposomes (AmB-LLs), but all antifungal drugs, including AmB-LLs, have serious limitations due to human toxicity and insufficient fungal cell killing. Even with...

    Suresh Ambati, Aileen R. Ferarro, S. Earl Kang, Jianfeng Lin, Xiaorong Lin, Michelle Momany, Zachary A. Lewis, Richard B. Meagher
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