bacteremia

  • Open Access
    <span class="sc">d</span>-Serine Degradation by <span class="named-content genus-species" id="named-content-1">Proteus mirabilis</span> Contributes to Fitness during Single-Species and Polymicrobial Catheter-Associated Urinary Tract Infection
    Research Article | Host-Microbe Biology
    d-Serine Degradation by Proteus mirabilis Contributes to Fitness during Single-Species and Polymicrobial Catheter-Associated Urinary Tract Infection

    Urinary tract infections are among the most common health care-associated infections worldwide, the majority of which involve a urinary catheter (CAUTI). Our recent investigation of CAUTIs in nursing home residents identified Proteus mirabilis, Enterococcus species, and Escherichia coli as...

    Aimee L. Brauer, Ashley N. White, Brian S. Learman, Alexandra O. Johnson, Chelsie E. Armbruster
  • Open Access
    Human Immunoglobulin G Cannot Inhibit Fibrinogen Binding by the Genetically Diverse A Domain of <span class="named-content genus-species" id="named-content-1">Staphylococcus aureus</span> Fibronectin-Binding Protein A
    Research Article | Host-Microbe Biology
    Human Immunoglobulin G Cannot Inhibit Fibrinogen Binding by the Genetically Diverse A Domain of Staphylococcus aureus Fibronectin-Binding Protein A

    Despite the many in vitro and murine in vivo studies involving FnBPA, the actual presence of this virulence factor during human infection is less well established. Furthermore, it is currently unknown to what extent sequence variation in such a virulence factor affects the human antibody response and the ability of antibodies to interfere with FnBPA function. This study sheds new light on these issues. First, the...

    P. Martijn den Reijer, Mehri Tavakol, Nicole Lemmens-den Toom, Dikra Allouch, Sheila Thomas, Vannakambadi K. Ganesh, Ya-Ping Ko, Henri A. Verbrugh, Willem J. B. van Wamel
  • Open Access
    Similarly Lethal Strains of Extraintestinal Pathogenic <span class="named-content genus-species" id="named-content-1">Escherichia coli</span> Trigger Markedly Diverse Host Responses in a Zebrafish Model of Sepsis
    Editor's Pick Research Article | Host-Microbe Biology
    Similarly Lethal Strains of Extraintestinal Pathogenic Escherichia coli Trigger Markedly Diverse Host Responses in a Zebrafish Model of Sepsis

    Sepsis is a life-threatening systemic inflammatory condition that is initiated by the presence of microorganisms in the bloodstream. In the United States, sepsis due to ExPEC and other pathogens kills well over a quarter of a million people each year and is associated with tremendous health care costs. A high degree of heterogeneity in the signs and symptomology of sepsis makes this disease notoriously difficult to effectively diagnose...

    Amelia E. Barber, Brittany A. Fleming, Matthew A. Mulvey
  • Open Access
    <span class="named-content genus-species" id="named-content-1">Acinetobacter baumannii</span> Genes Required for Bacterial Survival during Bloodstream Infection
    Research Article | Host-Microbe Biology
    Acinetobacter baumannii Genes Required for Bacterial Survival during Bloodstream Infection

    A. baumannii is a significant cause of bacterial bloodstream infection in humans. Since multiple antibiotic resistance is becoming more common among strains of A. baumannii, there is an urgent need to develop novel tools to treat infections caused by this dangerous pathogen. To develop...

    Sargurunathan Subashchandrabose, Sara Smith, Valerie DeOrnellas, Sebastien Crepin, Monica Kole, Carina Zahdeh, Harry L. T. Mobley
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