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Bacillus subtilis

  • Open Access
    SppI Forms a Membrane Protein Complex with SppA and Inhibits Its Protease Activity in <span class="named-content genus-species" id="named-content-1">Bacillus subtilis</span>
    Research Article | Molecular Biology and Physiology
    SppI Forms a Membrane Protein Complex with SppA and Inhibits Its Protease Activity in Bacillus subtilis

    Our study presents new insights into the molecular mechanism that regulates the activity of SppA, a widely conserved bacterial membrane protease. We show that the membrane proteins SppA and SppI form a complex in the Gram-positive model bacterium B. subtilis and that SppI inhibits SppA protease activity in vitro and in vivo. Furthermore, we...

    Gabriela Henriques, Stephen McGovern, Jolanda Neef, Minia Antelo-Varela, Friedrich Götz, Andreas Otto, Dörte Becher, Jan Maarten van Dijl, Matthieu Jules, Olivier Delumeau
  • Open Access
    The Major Chromosome Condensation Factors Smc, HBsu, and Gyrase in <span class="named-content genus-species" id="named-content-1">Bacillus subtilis</span> Operate via Strikingly Different Patterns of Motion
    Research Article | Molecular Biology and Physiology
    The Major Chromosome Condensation Factors Smc, HBsu, and Gyrase in Bacillus subtilis Operate via Strikingly Different Patterns of Motion

    All types of cells need to compact their chromosomes containing their genomic information several-thousand-fold in order to fit into the cell. In eukaryotes, histones achieve a major degree of compaction and bind very tightly to DNA such that they need to be actively removed to allow access of polymerases to the DNA. Bacteria have evolved a basic, highly dynamic system of DNA compaction, accommodating rapid adaptability to changes in...

    Sonja Schibany, Rebecca Hinrichs, Rogelio Hernández-Tamayo, Peter L. Graumann
  • Open Access
    Oxalate-Degrading <span class="named-content genus-species" id="named-content-1">Bacillus subtilis</span> Mitigates Urolithiasis in a <span class="named-content genus-species" id="named-content-2">Drosophila melanogaster</span> Model
    Research Article | Therapeutics and Prevention
    Oxalate-Degrading Bacillus subtilis Mitigates Urolithiasis in a Drosophila melanogaster Model

    Kidney stone disease is a morbid condition that is increasing in prevalence, with few nonsurgical treatment options. The majority of stones are composed of calcium oxalate. Unlike humans, some microbes can break down oxalate, suggesting that microbial therapeutics may provide a novel treatment for kidney stone patients. This study demonstrated that Bacillus subtilis...

    Kait F. Al, Brendan A. Daisley, Ryan M. Chanyi, Jennifer Bjazevic, Hassan Razvi, Gregor Reid, Jeremy P. Burton
  • Open Access
    Integrative Analysis of Proteome and Transcriptome Dynamics during <span class="named-content genus-species" id="named-content-1">Bacillus subtilis</span> Spore Revival
    Research Article | Molecular Biology and Physiology
    Integrative Analysis of Proteome and Transcriptome Dynamics during Bacillus subtilis Spore Revival

    This study demonstrated the progress of macromolecular synthesis during Bacillus subtilis spore germination and outgrowth. The transcriptome analysis has additionally allowed us to trace gene expression during this transformation process. For the first time, the basic survival kit for spore-based life has been identified. In addition, in this analysis based on...

    Bhagyashree Swarge, Wishwas Abhyankar, Martijs Jonker, Huub Hoefsloot, Gertjan Kramer, Peter Setlow, Stanley Brul, Leo J. de Koning
  • Open Access
    Architecture and Self-Assembly of <span class="named-content genus-species" id="named-content-1">Clostridium sporogenes</span> and <span class="named-content genus-species" id="named-content-2">Clostridium botulinum</span> Spore Surfaces Illustrate a General Protective Strategy across Spore Formers
    Research Article | Molecular Biology and Physiology
    Architecture and Self-Assembly of Clostridium sporogenes and Clostridium botulinum Spore Surfaces Illustrate a General Protective Strategy across Spore Formers

    Bacteria such as those causing botulism and anthrax survive harsh conditions and spread disease as spores. Distantly related species have similar spore architectures with protective proteinaceous layers aiding adhesion and targeting. The structures that confer these common properties are largely unstudied, and the proteins involved can be very dissimilar in sequence. We identify CsxA as a cysteine-rich protein that self-assembles in a...

    Thamarai K. Janganan, Nic Mullin, Ainhoa Dafis-Sagarmendi, Jason Brunt, Svetomir B. Tzokov, Sandra Stringer, Anne Moir, Roy R. Chaudhuri, Robert P. Fagan, Jamie K. Hobbs, Per A. Bullough
  • Open Access
    Chromosome Segregation in <span class="named-content genus-species" id="named-content-1">Bacillus subtilis</span> Follows an Overall Pattern of Linear Movement and Is Highly Robust against Cell Cycle Perturbations
    Research Article | Molecular Biology and Physiology
    Chromosome Segregation in Bacillus subtilis Follows an Overall Pattern of Linear Movement and Is Highly Robust against Cell Cycle Perturbations

    We have followed the segregation of origin regions on the Bacillus subtilis chromosome in the fastest practically achievable temporal manner, for a large fraction of the cell cycle. We show that segregation occurred in highly variable patterns but overall in an almost linear manner throughout the cell cycle. Segregation was slowed down, but not arrested, by treatment...

    Nina El Najjar, David Geisel, Felix Schmidt, Simon Dersch, Benjamin Mayer, Raimo Hartmann, Bruno Eckhardt, Peter Lenz, Peter L. Graumann
  • Open Access
    mSphere of Influence: Comprehensive Genetic Analysis
    Commentary | Molecular Biology and Physiology
    mSphere of Influence: Comprehensive Genetic Analysis

    Jason M. Peters works in the fields of antibiotic resistance and biofuel production. In this mSphere of Influence article, he reflects on how the paper “A global genetic interaction network maps a wiring diagram of cellular function” by Costanzo et al. (Science 353:aaf1420, 2016, https://doi.org/10.1126/science.aaf1420) has impacted his work by highlighting the power of gene networks...

    Jason M. Peters
  • Open Access
    Biofilm Formation Drives Transfer of the Conjugative Element ICE<em>Bs1</em> in <em>Bacillus subtilis</em>
    Research Article | Applied and Environmental Science
    Biofilm Formation Drives Transfer of the Conjugative Element ICEBs1 in Bacillus subtilis

    Transfer of mobile genetic elements from one bacterium to another is the principal cause of the spread of antibiotic resistance. However, the dissemination of these elements in environmental contexts is poorly understood. In clinical and environmental settings, bacteria are often found living in multicellular communities encased in a matrix, a structure known as a biofilm. In this study, we examined how forming a biofilm influences the...

    Frédéric Lécuyer, Jean-Sébastien Bourassa, Martin Gélinas, Vincent Charron-Lamoureux, Vincent Burrus, Pascale B. Beauregard
  • Open Access
    Antibiotic Stimulation of a <span class="named-content genus-species" id="named-content-1">Bacillus subtilis</span> Migratory Response
    Research Article | Molecular Biology and Physiology
    Antibiotic Stimulation of a Bacillus subtilis Migratory Response

    Antibiotic resistance is a major challenge for the effective treatment of infectious diseases. Identifying adaptive mechanisms that bacteria use to survive low levels of antibiotic stress is important for understanding pathways to antibiotic resistance. Furthermore, little is known about the effects of individual bacterial interactions on multispecies communities. This work demonstrates that subinhibitory amounts of some antibiotics...

    Yongjin Liu, Steven Kyle, Paul D. Straight
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