assay development

  • Open Access
    Development and Standardization of a High-Throughput Multiplex Immunoassay for the Simultaneous Quantification of Specific Antibodies to Five Respiratory Syncytial Virus Proteins
    Research Article | Clinical Science and Epidemiology
    Development and Standardization of a High-Throughput Multiplex Immunoassay for the Simultaneous Quantification of Specific Antibodies to Five Respiratory Syncytial Virus Proteins

    In view of vaccine and monoclonal development to reduce hospitalization and death due to lower respiratory tract infection caused by RSV, assessment of antibody levels against RSV is essential. This newly developed multiplex immunoassay is able to measure antibody levels against five RSV proteins simultaneously. This can provide valuable insight into the dynamics of (maternal) antibody levels and RSV infection in infants and toddlers...

    Rutger M. Schepp, Cornelis A. M. de Haan, Deidre Wilkins, Hans Layman, Barney S. Graham, Mark T. Esser, Guy A. M. Berbers
  • Open Access
    Improved Subtyping of <span class="named-content genus-species" id="named-content-1">Staphylococcus aureus</span> Clonal Complex 8 Strains Based on Whole-Genome Phylogenetic Analysis
    Editor's Pick Research Article | Clinical Science and Epidemiology
    Improved Subtyping of Staphylococcus aureus Clonal Complex 8 Strains Based on Whole-Genome Phylogenetic Analysis

    Staphylococcus aureus is a major human pathogen worldwide in both community and health care settings. Surveillance for S. aureus strains is important to our understanding of their spread and to informing infection prevention and control. Confusion surrounding the strain nomenclature of one of the...

    Jolene R. Bowers, Elizabeth M. Driebe, Valerie Albrecht, Linda K. McDougal, Mitchell Granade, Chandler C. Roe, Darrin Lemmer, J. Kamile Rasheed, David M. Engelthaler, Paul Keim, Brandi M. Limbago
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