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apoptosis

  • Open Access
    Human Cytomegalovirus UL7, miR-US5-1, and miR-UL112-3p Inactivation of FOXO3a Protects CD34<sup>+</sup> Hematopoietic Progenitor Cells from Apoptosis
    Research Article | Host-Microbe Biology
    Human Cytomegalovirus UL7, miR-US5-1, and miR-UL112-3p Inactivation of FOXO3a Protects CD34+ Hematopoietic Progenitor Cells from Apoptosis

    Human cytomegalovirus (HCMV) causes serious disease in immunocompromised individuals and is a significant problem during transplantation. The virus can establish a latent infection in CD34+ hematopoietic progenitor cells (HPCs) and periodically reactivate to cause disease in the absence of an intact immune system.

    Meaghan H. Hancock, Lindsey B. Crawford, Wilma Perez, Hillary M. Struthers, Jennifer Mitchell, Patrizia Caposio
  • Open Access
    Analysis of Apoptosis-Related Genes Reveals that Apoptosis Functions in Conidiation and Pathogenesis of <em>Fusarium pseudograminearum</em>
    Research Article | Host-Microbe Biology
    Analysis of Apoptosis-Related Genes Reveals that Apoptosis Functions in Conidiation and Pathogenesis of Fusarium pseudograminearum

    The plant-pathogenic fungus F. pseudograminearum is the causal agent of Fusarium crown rot (FCR) in wheat and barley, resulting in substantial yield losses worldwide. Particularly, in the Huanghuai wheat-growing region of China, F. pseudograminearum was reported as the dominant Fusarium species in FCR infections.

    Linlin Chen, Yuming Ma, Mengya Peng, Wenbo Chen, Huiqing Xia, Jingya Zhao, Yake Zhang, Zhuo Fan, Xiaoping Xing, Honglian Li
  • Open Access
    Live <em>In Vivo</em> Imaging of <em>Plasmodium</em> Invasion of the Mosquito Midgut
    Research Article | Host-Microbe Biology
    Live In Vivo Imaging of Plasmodium Invasion of the Mosquito Midgut

    Malaria is one of the most devastating parasitic diseases in humans and is transmitted by anopheline mosquitoes. The mosquito midgut is a critical barrier that Plasmodium parasites must overcome to complete their developmental cycle and be transmitted to a new host. Here, we developed a new strategy to visualize Plasmodium ookinetes as they traverse the mosquito midgut and to follow the response of damaged epithelial...

    Nathanie Trisnadi, Carolina Barillas-Mury
  • Open Access
    Label-Free Digital Holo-tomographic Microscopy Reveals Virus-Induced Cytopathic Effects in Live Cells
    Editor's Pick Research Article | Host-Microbe Biology
    Label-Free Digital Holo-tomographic Microscopy Reveals Virus-Induced Cytopathic Effects in Live Cells

    This study introduces label-free digital holo-tomographic microscopy (DHTM) and refractive index gradient (RIG) measurements of live, virus-infected cells. We use DHTM to describe virus type-specific cytopathic effects, including cyclic volume changes of vaccinia virus infections, and cytoplasmic condensations in herpesvirus and rhinovirus infections, distinct from apoptotic cells. This work shows for the first time that DHTM is...

    Artur Yakimovich, Robert Witte, Vardan Andriasyan, Fanny Georgi, Urs F. Greber
  • Open Access
    <span class="named-content genus-species" id="named-content-1">Ehrlichia chaffeensis</span> TRP75 Interacts with Host Cell Targets Involved in Homeostasis, Cytoskeleton Organization, and Apoptosis Regulation To Promote Infection
    Research Article | Host-Microbe Biology
    Ehrlichia chaffeensis TRP75 Interacts with Host Cell Targets Involved in Homeostasis, Cytoskeleton Organization, and Apoptosis Regulation To Promote Infection

    Human monocytic ehrlichiosis (HME) is caused by an obligatory intracellular bacterium, E. chaffeensis, and is one of the most prevalent, life-threatening emerging infectious zoonoses in the United States. The mechanisms through which E. chaffeensis invades and establishes an intracellular niche are not well understood but are dependent on secreted ehrlichial effector proteins. The significance of this study is in addressing how...

    Tian Luo, Shubhajit Mitra, Jere W. McBride
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