apicomplexa
Research ArticleExpanding the Known Repertoire of C-Type Lectin Receptors Binding to Toxoplasma gondii Oocysts Using a Modified High-Resolution Immunofluorescence AssayKnowledge of oocyst biology of Toxoplasma gondii is limited, not the least due to its limited availability. We describe a method that allowed us to process minute amounts of oocysts for immunofluorescence microscopy without compromising their structural properties.
Observation | Molecular Biology and PhysiologyDispensable Role of Mitochondrial Fission Protein 1 (Fis1) in the Erythrocytic Development of Plasmodium falciparumMalaria is responsible for over 230 million clinical cases and ∼half a million deaths each year. The single mitochondrion of the malaria parasite functions as a metabolic hub throughout the parasite’s developmental cycle (DC) and also as a source of ATP in certain stages. To pass on its essential functions, the parasite’s mitochondrion needs to be properly divided and segregated into all progeny during cell division via a process termed...
Research Article | Molecular Biology and PhysiologyToxoplasma gondii AP2XII-2 Contributes to Proper Progression through S-Phase of the Cell CycleToxoplasma gondii is a single-celled parasite that persists in its host by converting into a latent cyst stage. This work describes a new transcriptional factor called AP2XII-2 that plays a role in properly maintaining the growth rate of replicating parasites, which contributes to signals required for development into its dormant stage. Without AP2XII-2, ...
Research Article | Host-Microbe BiologySimultaneous Ribosome Profiling of Human Host Cells Infected with Toxoplasma gondiiToxoplasma gondii is a single-celled parasite that has infected up to one-third of the world’s population. Significant overhauls in gene expression in both the parasite and the host cell accompany parasite invasion, and a better understanding of these changes may lead to the development of new therapeutic agents. In this study, we employed ribosome profiling to...