antibody function

  • Open Access
    Humoral Immunity to Hantavirus Infection
    Minireview | Host-Microbe Biology
    Humoral Immunity to Hantavirus Infection

    Hantaviruses are pathogens that sometimes pass from animals to humans, and they are found in parts of Europe, Asia, and North and South America. When human infection occurs, these viruses can cause kidney or lung failure, and as many as 40% of infected people die. Currently, there are no vaccines or therapeutics for hantavirus-related diseases available. A first step in developing prevention measures is determining what type of immune...

    Taylor B. Engdahl, James E. Crowe
  • Open Access
    Human Immunoglobulin G Cannot Inhibit Fibrinogen Binding by the Genetically Diverse A Domain of <span class="named-content genus-species" id="named-content-1">Staphylococcus aureus</span> Fibronectin-Binding Protein A
    Research Article | Host-Microbe Biology
    Human Immunoglobulin G Cannot Inhibit Fibrinogen Binding by the Genetically Diverse A Domain of Staphylococcus aureus Fibronectin-Binding Protein A

    Despite the many in vitro and murine in vivo studies involving FnBPA, the actual presence of this virulence factor during human infection is less well established. Furthermore, it is currently unknown to what extent sequence variation in such a virulence factor affects the human antibody response and the ability of antibodies to interfere with FnBPA function. This study sheds new light on these issues. First, the...

    P. Martijn den Reijer, Mehri Tavakol, Nicole Lemmens-den Toom, Dikra Allouch, Sheila Thomas, Vannakambadi K. Ganesh, Ya-Ping Ko, Henri A. Verbrugh, Willem J. B. van Wamel
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