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    • mSphere of Influence: Commentaries from Early Career Microbiologists
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aging

  • Open Access
    Age-Related Variation of Bacterial and Fungal Communities in Different Body Habitats across the Young, Elderly, and Centenarians in Sardinia
    Research Article | Host-Microbe Biology
    Age-Related Variation of Bacterial and Fungal Communities in Different Body Habitats across the Young, Elderly, and Centenarians in Sardinia

    Site-specific microbial communities are recognized as important factors in host health and disease. To better understand how the human microbiota potentially affects and is affected by its host during the aging process, the fundamental issue to address is the distribution of microbiota related to age. Here, we show an integrated view of the spatial distribution of microbes in a specific Mediterranean population (Sardinians) across a...

    Lu Wu, Tiansheng Zeng, Massimo Deligios, Luciano Milanesi, Morgan G. I. Langille, Angelo Zinellu, Salvatore Rubino, Ciriaco Carru, David J. Kelvin
  • Open Access
    Minicells as a Damage Disposal Mechanism in <span class="named-content genus-species" id="named-content-1">Escherichia coli</span>
    Research Article | Molecular Biology and Physiology
    Minicells as a Damage Disposal Mechanism in Escherichia coli

    Bacteria have the ability to produce minicells, or small spherical versions of themselves that lack chromosomal DNA and are unable to replicate. A minicell can constitute as much as 20% of the cell’s volume. Although molecular biology and biotechnology have used minicells as laboratory tools for several decades, it is still puzzling that bacteria should produce such costly but potentially nonfunctional structures. Here, we show that...

    Camilla U. Rang, Audrey Proenca, Christen Buetz, Chao Shi, Lin Chao
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