TABLE 1

Estimated diagnostic sensitivity, diagnostic specificity, and analytical specificity of the 3 commercial TGEV/PRCV blocking ELISA kits evaluated in this study

ParameterGroup% (95 confidence interval [%]) by assay and suspect result categorization
Suspect results as positiveSuspect results as negative
SwinecheckINgezimSvanovirSwinecheckINgezimSvanovir
Diagnostic sensitivityaTGEV Purdue65 (63, 95)65 (49, 81)79 (61, 90)51 (36, 70)54 (38, 72)50 (33, 67)
TGEV Miller94 (81, 99)93 (81, 99)78 (60, 89)94 (81, 99)82 (67, 94)54 (38, 72)
TGEVd80 (64, 92)79 (64, 92)78 (60, 89)73 (55, 86)68 (64, 92)53 (36, 70)
PRCV86 (71, 95)85 (71, 95)28 (14, 15)86 (71, 95)81 (64, 92)28 (14, 15)
Diagnostic specificitybTGEV100 (90, 100)100 (90, 100)100 (90, 100)100 (90, 100)100 (90, 100)100 (90, 100)
PRCV100 (90, 100)99 (90, 100)100 (90, 100)100 (90, 100)99 (90, 100)100 (90, 100)
Analytical specificitycTGEV Purdue63 (46, 79)70 (52, 83)71 (52, 84)63 (46, 79)70 (52, 84)72 (55, 86)
TGEV Miller91 (78, 98)95 (81, 99)76 (58, 88)92 (78, 98)95 (81, 99)84 (67, 94)
TGEVd77 (61, 90)82 (67, 94)73 (55, 86)77 (61, 90)82 (67, 94)78 (61, 90)
PRCV82 (67, 94)84 (67, 94)39 (23, 57)87 (71, 95)93 (78, 98)95 (81, 99)
  • a The diagnostic sensitivity of each kit was calculated according to diagnosed and true statuses of each group on dpi 14 to 42 (considered positive status).

  • b The diagnostic specificity of each test was calculated according to diagnosed TGEV or PRCV status in the negative-control group on dpi −7 and 42.

  • c The analytical specificity of each test was calculated according to TGEV or PRCV status across groups between dpi 7 and 42.

  • d Combined results from pigs inoculated with both TGEV Purdue and Miller strains.