TABLE 1

Summary of meningococcal carriage prevalence rates at each visit by isolate PCR (ITT population)g

Visit
(swab)
CohortAge group
(Ne)
N. meningitidis serogroup detection from throat swab, n (%)a,b
NmBcNmCNmYNmWNongroupableNmE or
NmZ
All
non-NmBd
All
meningococci
Visit 119th grade (533)4 (0.8)2 (0.4)8 (1.5)4 (0.8)16 (3.0)3 (0.6)33 (6.2)37 (6.9)
11th gradef (363)4 (1.1)1 (0.3)3 (0.8)1 (0.3)10 (2.8)2 (0.6)17 (4.7)21 (5.8)
2University (360)20 (5.6)3 (0.8)5 (1.4)8 (2.2)35 (9.7)16 (4.4)67 (18.6)87 (24.2)
Visit 219th grade (417)7 (1.7)1 (0.2)4 (1.0)1 (0.2)15 (3.6)0 (0.0)21 (5.0)28 (6.7)
11th grade (363)5 (1.4)1 (0.3)2 (0.6)0 (0.0)8 (2.2)2 (0.6)13 (3.6)18 (5.0)
2University (356)16 (4.5)3 (0.8)3 (0.8)6 (1.7)31 (8.7)9 (2.5)52 (14.6)68 (19.1)
Visit 319th grade (526)8 (1.5)1 (0.2)5 (1.0)3 (0.6)14 (2.7)1 (0.2)24 (4.6)32 (6.1)
College entry (356)4 (1.1)0 (0.0)2 (0.6)1 (0.3)12 (3.4)3 (0.8)18 (5.1)22 (6.2)
2University (339)17 (5.0)4 (1.2)6 (1.8)7 (2.1)27 (8.0)8 (2.4)52 (15.3)69 (20.4)
Any visit19th grade (533)11 (2.1)2 (0.4)9 (1.7)5 (0.9)19 (3.6)3 (0.6)39 (7.3)49 (9.2)
11th grade/college
entry (363)
6 (1.7)1 (0.3)4 (1.1)1 (0.3)17 (4.7)3 (0.8)26 (7.2)32 (8.8)
2University (360)27 (7.5)4 (1.1)8 (2.2)9 (2.5)42 (11.7)15 (4.2)79 (21.9)105 (29.1)
  • a n (%) is the number and percentage of subjects with positive meningococci carriage at that visit.

  • b No NmA or NmX isolates were detected.

  • c NmB PCR data were confirmed by WGS.

  • d All non-NmB meningococci: A, C, X, Y, W, nongroupable, Z, and E.

  • e N is number of subjects who had a culture performed at that visit.

  • f Eleventh-grade/college-entry students are the same (former) ninth-grade students.

  • g Abbreviations: ITT, intent-to-treat; Nm, Neisseria meningitidis; isolate PCR assay was performed by real-time PCR. Non-NmB meningococci include any sample in which the porA and/or ctrA gene(s) was detected but the group B capsule gene was not detected. Missing data were not imputed.